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The Way Forward in the UK

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Presentation on theme: "The Way Forward in the UK"— Presentation transcript:

1 The Way Forward in the UK
TrueAllele® Workshop April, 2013 Leicestershire, United Kingdom Mark W Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics © Cybergenetics ©

2 TrueAllele mixture validation: Virginia case study
Perlin MW et al. Virginia TrueAllele® vaildation study: casework comparison. American Academy of Forensic Sciences 65th Annual Meeting, 2013; Washington, DC. TrueAllele mixture validation: Virginia case study Establish the reliability of TrueAllele mixture interpretation Mark W Perlin, PhD, MD, PhD Kiersten Dormer, MS and Jennifer Hornyak, MS Cybergenetics, Pittsburgh, PA Lisa Schiermeier-Wood, MS and Susan Greenspoon, PhD Department of Forensic Science, Richmond, VA Cybergenetics ©

3 Case composition • 72 criminal cases • 92 evidence items
• 111 genotype comparisons Criminal offense • 18 homicide • 12 robbery • 6 sexual assault • 20 weapon

4 DNA mixture distribution

5 Human review information
2.26 HR1 6.70 Nothing reported 25

6 2010 guidelines: modified human review information
2.26 56 HR1 HR2 1.75 2.12 6.70 Nothing reported 25

7 TrueAllele reinterpretation
Virginia reevaluates DNA evidence in 375 cases July 16, 2011 “Mixture cases are their own little nightmare,” says William Vosburgh, director of the D.C. police’s crime lab. “It gets really tricky in a hurry.” “If you show 10 colleagues a mixture, you will probably end up with 10 different answers” Dr. Peter Gill, Human Identification E-Symposium, 2005

8 TrueAllele sensitivity
2.26 56 HR1 HR2 TrueAllele 1.75 5.52 2.12 6.70 10.93 Nothing reported 25 9

9 TrueAllele specificity
True exclusions, without false inclusions – 19.69

10 TrueAllele reproducibility
Concordance in two independent computer runs standard deviation (within-group) 0.305 log(LR2) log(LR1)

11 TrueAllele computer genotyping is more effective than human review
Validation results TrueAllele® Casework DNA mixture interpretation is: A reliable method • sensitive • specific • reproducible TrueAllele computer genotyping is more effective than human review

12 TrueAllele Virginia outcomes
144 cases analyzed 72 case reports – 10 trials City Court Charge Sentence Richmond Federal Weapon 50 years Alexandria Bank robbery 90 years Quantico Military Rape 3 years Chesapeake State Robbery 26 years Arlington Molestation 22 years Homicide 35 years Fairfax Abduction 33 years Norfolk 8 years Charlottesville 15 years Hampton Home invasion 5 years

13 TrueAllele in Virginia
• Department of Forensic Science has their own TrueAllele system • Training, validation, approvals • Services centralized in Richmond • DFS will provide DNA mixture statistics and court testimony

14 Perlin MW, Belrose JL, Duceman BW
Perlin MW, Belrose JL, Duceman BW. New York State TrueAllele® Casework validation study. Journal of Forensic Sciences. 2013;58(6):in press. TrueAllele in New York

15 TrueAllele in the United States
Casework system Interpretation services

16 TrueAllele in the United Kingdom
2000: FSS & TrueAllele Databank • first fully automated DNA expert system • for reference samples only • faster: eliminated 350,000 item backlog • better: eliminated human error of 0.05% • cheaper: eliminated 100 jobs 2010: PSNI & TrueAllele Casework • match stats for complex DNA evidence • 3-4 person DNA mixtures • low-template & degraded DNA

17 DNA Pathway Restored Lab Infer Evidence item Evidence data
Evidence genotype 10, 30% 10, 50% 10, 20% + Compare Known genotype 10, 12

18 TrueAllele Applications
• murder • rape • gangs • terror • IEDs • cold cases • DVI • property crime • prevention

19 Real Information, Real Time
Evidence Genotype database Infer & Upload Crime scene +

20 Real Information, Real Time
Evidence Reference Genotype database Genotype database Infer & Upload Crime scene Criminals +

21 Real Information, Real Time
Evidence Reference Genotype database Genotype database Match & Report Infer & Upload Crime scene Criminals +

22 Continuous Crime Scene Mapping
Suspects: S1, S2, S3, S4, S5 Market • hat 1 • hat 2 • overalls • shirt Food mart • gun • hat Jewelry • counter • safe Convenience • keys • tape Hardware • safe • phone

23 TrueAllele Deployment
• in the cloud (Cybergenetics service) • in your station or laboratory (Cybergenetics product)

24 Police Empowerment • TrueAllele-led DNA investigation
• solve challenging DNA evidence • train TrueAllele police personnel • accurate DNA interpretation • faster turnaround • less human effort • consistent answers • preserve identification information • DNA evidence within cases • automated investigative database

25 Getting Started

26 Moving Forward • Send one case (no cost) • Discuss match results
• Assess TrueAllele value • Identify additional cases • Determine business case • Rent or buy technology • Training and support

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