1. Resistance management in North America
North American FRAC and NAQoI
Hendrik L. Ypema - BASF Corporation Roger P. Kaiser - Bayer CropScience Research Triangle Park North Carolina, USA

2. Objectives for NAFRAC Promote FRAC objectives in North America
Provide a local voice for Industry to Regulatory Agencies
Insure adoption of sound resistance management practices with clear rules and recommendations that fit local needs
November 18,2002

3. Drivers of resistance management guidelines in North America
Regulatory effort: US EPA and Canada PMRA
Industry effort: NAFRAC and NAQoI
University and Extension recommendations (Influences)
November 18,2002

4. Fungicide Resistance Management The Regulatory Basis
Canada (PMRA): Regulatory Directive 99-06, Oct [
PMRA encourages adoption of voluntary guidelines for all new and existing products - Target date: all labels with guidelines by Jan. 1, 2004
USEPA guidelines: PR Notice , June 2001 [
EPA encourages adoption of voluntary guidelines for all new and existing products (No timeframe as EPA lacks clear legal authority to impose guidelines)
November 18,2002

5. Importance of the Label in NA
The label is a legal and public document
Not following restrictions on the label is a violation of the law
Restriction examples:
Sentences starting with “do not”
Sentence starting with an imperative verb
It is not a violation to not follow label recommendations
Recommendation examples
Sentences incorporating words like “should”, or “it is recommended”
November 18,2002

6. USEPA and PMRA Guidelines
Objectives
Provide a common scheme of classification of pesticides according to target site/mode of action, using a standard format
(For example: QoI’s are Group 11)
Group identification symbols on the end-use product labels
Guidelines for labeling resistance-management strategies in the use directions
November 18,2002

7. PR Notice 2001-5 – Numerical Classification
Front-panel of the label – typically in the center)
(one active ingredient, one mode of action)
(multiple active ingredients with different mode of action)
GROUP FUNGICIDE 1
GROUP FUNGICIDES
November 18,2002

8. PR Notice 2001-5 Directions for Use
Avoid repeated, consecutive use of the same MOA
Use tank mixes or premixes from a different MOA
Use an effective IPM program
Monitor fields for loss of fungicide efficacy
Contact field experts for resistance management advice
Contact the producer to report loss of efficacy
November 18,2002

9. Canada Implementation
PMRA encourages adoption of voluntary guidelines for all new and existing products - Target date Jan. 1, 2004
24 product labels to date
PMRA increase efforts:
Adding resistance management text to draft label
Need to identify barriers
The resistance management labeling progress will be reassessed on a yearly basis to determine if further action is needed
Adding the guidelines is a requirement for joint review of pesticide labels
November 18,2002

10. US Implementation
EPA encourages adoption of voluntary guidelines for all new and existing products (no timeframe)
Add classification and labeling statements by notification
New a.i.s and amendments on priority list over time
Reduced Risk Screening Process
Adding the guidelines is a requirement for joint review of pesticide labels
November 18,2002

11. High Priority Issues Monitoring for resistance (label language)
Should there be scientifically valid monitoring or
Notification of field failures with follow-up
Identification of new Groups (Coordinate with FRAC)
‘U’ and ‘P’ are unacceptable because of proposed label language.
November 18,2002

12. North American FRAC
Manage the adoption of resistance management language on fungicide labels
Keep our organization small - create new working groups only on an “as needed” basis
Provide resource to NA:
speakers
publications
web-site
November 18,2002