1. 1 Final Session SEARCH MULTIPLE RESOURCES Knowledge Assessment Merck Manual of Diagnosis and Therapy Medline (PubMed) Cochrane Library Clinical Evidence Science–Technology–Medicine + Cited Reference Search + Journal Impact Factor

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3. 3 Searching – Finding - Appraising Enuresis (Bedwetting) in school children: Treatment options

4. 4 CLINICAL QUESTION FOR TODAY  Case 11-year old boy with enuresis (bedwetting) Urinary tract infections excluded; Frustrated with his health problem Possible treatment options: 1. Drug therapy (desmopressin) 2. Enuresis alarm 3. Combination of desmopressin + alarm? Adapated from:BMJLearning http://http://learning.bmj.comhttp://learning.bmj.com

5. 5 BACKGROUND INFORMATION  Definition of enuresis (bedwetting) Merck Manual of Diagnosis and Therapy http://www.merckmanual.com Search: enuresis +desmopressin +alarms

6. 6 Enuresis – what it is about Primary nocturnal enuresis  Failure to have developed bedtime bladder control  Usually caused by slow maturation of the nerves that supply the bladder  The child fails to awaken appropriately when the bladder fills and needs emptying. affects 30% of children at age 4, 10% at age 6, 3% at age 12, and 1% at age 18.  It is more common in boys,  Seems to be familial,  Sometimes associated with sleep disorders.

7. 7 FOREGROUND QUESTION Terminology  enuresis; enuretic; bedwet; bedwetting  drug(s); desmopressin;  alarm(s)

8. 8 PubMed Search Strategy Suggestions Step 1 enure* OR bedwet* Limits: Title Step 2 desmopressin* OR drug* OR alarm* Limits: Title Step 3 Combine searches #1 AND #2 Step 4 Limits: Ages: Child 6-12

9. 9 PubMed Search Results (1)

10. 10 PubMed Search Results (2)  All: 224 Reviews: 25  8 Cochrane Reviews of randomized controlled trials

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12. 12 Combination treatment Drugs + alarms

13. 13 Professional Databases with Critically Appraised Topics Clinical Evidence http://www.clinicalevidence.comhttp://www.clinicalevidence.com (fee)  Systematic reviews Question(s)  Option(s)  Grades of evidence Beneficial Likely beneficial Trade off between benefit and harm Unknown effectiveness Unlikely beneficial Etc.

14. 14 Clinical Evidence Interventions: Questions

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16. 16 CRITICAL APPRAISAL „Bibliometric Criteria“ Multidisciplinary database WEB OF KNOWLEDGE  Which journal was it written in? „Impact Factor“ = journal quality  Additional resources  Journal Citation Reports (part of WoS)  Who wrote the article? Was the article cited by other articles?  Web of Science (part of WoK)  Science Citation Index (tool)

17. 17 WEB OF SCIENCE Multidisciplinary Database Palacky University Authorized Access at: http://isiknowledge.com  Search  Cited Reference Search  Journal Citation Reports

18. 18 Which journal was it published in ? Journal Impact Factor http://isiknowledge.com Additional Resources – Journal Citation Reports  Cited author(s): Naitoh Y et al.  Article title: Combination therapy with alarm and drugs for monosymptomatic nocturnal enuresis not superior to alarm monotherapy..  Cited work: Urology  Publication Year: 2005  Volume/Issue: 660/3  Pagination: 632-635.

19. 19 Search for a specific journal ….. Urology

20. 20 Urology Impact Factor 2005 = 2.139

21. 21 Urology Impact Factor Calculation Calculation  Number of articles published in: 2004 = 584 + 2003 = 599 Sum: 1183  Number of cites in 2005 to articles published in: 2004 = 897 + 2003 = 1634 Sum: 2531 Cites to articles 2531 Number of articles 1183 = 2.139 Impact factor

22. 22 Was article cited by other articles? Science Citation Index (SCI) http://isiknowledge.com CITED REFERENCE SEARCH  Cited author(s): Naitoh Y et al.  Article title: Combination therapy with alarm and drugs for monosymptomatic nocturnal enuresis not superior to alarm monotherapy..  Cited work: Urology  Publication Year: 2005  Volume/Issue: 660/3  Pagination: 632-635.

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25. 25 MORE ABOUT BIBLIOMETRICS  Introduced in 1960s …„application of mathematical and statistical methods to books and other media of communication“

26. 26 INSTITUTE FOR SCIENTIFIC INFORMATION & ITS FOUNDER  Eugene Garfield. Ph.D. www.garfield.library.upenn.edu  1951 career in scientific communication and information science  1960 founded ISI  2001- President, The Scientist.

27. 27 SCIENCE CITATION INDEX (SCI)  has become the most generally accepted source of bibliometrics.  Citations became a widely used measure of the impact of scientific publications as signposts left behind after information has been utilized.

28. 28 CRITICAL APPRAISAL In general Technique, skill  Increasing effectiveness of your reading  Excluding poorly designed studies  Helping decide which articles could influence your daily work which are unsuitable.