1. Pharmanex
Product Training

2. Cortitrol: Dietary Supplement
Cortitrol is a supplement that assists you in dealing with difficult situations.
Take Control!

3. Introducing Cortitrol
What is Cortitrol?
Introducing Cortitrol
Cortitrol is a unique dietary supplement that addresses the symptoms of a fast-paced lifestyle.
Cortitrol’s ingredients balance the level of cortisol in the body.

4. What is Cortisol? Background
Cortisol is a hormone produced by your body in response to difficult events.
The occasional release of cortisol is essential to respond to emergency situations. Too frequent release of cortisol can lead to health problems.

5. What is Cortisol? Cortisol The role of Cortisol in
Health and Longevity.

6. What is Cortisol? Today’s Health Demons 1980’s = Cholesterol
Early 1990’s = Free Radicals / Antioxidants
Later 1990’s = Insulin / Blood Sugar
2000’s = Cortisol

7. What is Cortisol? Cortisol in the Media
More Than 1,000 News Articles Over the Past Year!
Time, Washington Post, Reader’s Digest, etc
1st International Symposium on Cortisol, Stress and Health
May 2002
New Book: The Cortisol Connection...Why Stress Makes You Fat & Ruins Your Health…And What You Can Do About It
Published September 2002

8. What is Cortisol? The body’s primary stress hormone:
“Fight-or-Flight” response
Required by the body for survival
Regulates inflammation, carbohydrate metabolism, cardiovascular function, etc…
BUT too much of cortisol for too long leads to problems:
Repeated exposure to stressful situations (personal, family, work)
Modern stressors do not permit “fight-or-flight”
Stress hormones do not dissipate
Stress can lead to degenerative health consequences

9. What is Cortisol? STRESS ACUTE STRESS brief normal circadian rhythm
adaptive
CHRONIC STRESS
prolonged & repeated
disrupted circadian rhythm
maladaptive

10. Repeated Stress Elevates Cortisol
What is Cortisol?
Repeated Stress Elevates Cortisol

11. What is Cortisol?
The Relationship Between Elevated Cortisol and Stress Related Conditions
Scientific Evidence

12. Impact of Elevated Cortisol in:
What is Cortisol?
Impact of Elevated Cortisol in:
Obesity & Metabolic Syndrome
High cortisol secretion = abdominal fat = illness
Suppressed Immunity
Associated with low counts of white blood cells
Acute psycholsocial and sleep deprivation stress disrupts skin barrier homeostasis
Changes due in part from increased cortisol levels.

13. Impact of Elevated Cortisol in:
What is Cortisol?
Impact of Elevated Cortisol in:
Appetite
People who diet have high cortisol secretion
Bone Metabolism
High cortisol secretion = dietary restraint = implications for bone health

14. What is Cortisol? Other Research
Additional research has also identified many other health issues associated with elevated cortisol levels.

15. Stress and Health Care Costs
Work Demands
Increased
Health
Care Costs
$$$
Cortisol
Reactivity
Job Control
Ganster et al. Journal of Applied Psychology, 2001, 86,

16. Cortisol Levels are Elevated in…
What is Cortisol?
Cortisol Levels are Elevated in…
Chronic Stress
Sleep Deprivation
Dieting / Restrained Eating
Adults who need to control cortisol levels:
Get less than 8 hours sleep
Feel run-down, lack of mental focus
Limit caloric intake to lose weight
Often in difficult situations

17. The Market: Prevalence of Chronic Stress
80% of workers report feeling stress on the job
Stress contributes to half of all illnesses in the US
70-80% of all doctor visits are stress-related
>50% all deaths between the ages of 1 and 65 result from stress
Sources: U.S. Center for Disease Control; World Health Organization; Gallup Poll “Attitudes in the American Workplace”

18. The Market: Prevalence of Chronic Stress
Generalised anxiety disorder affects an estimated 183 million people worldwide
People who live in a high state of anxiety are 4.5 times more likely to die prematurely
Sources: U.S. Center for Disease Control; World Health Organization; Gallup Poll “Attitudes in the American Workplace”

19. The Solution: Cortisol Management
You can control cortisol levels via:
Stress Management Techniques
Meditation, coping strategies, etc…
Exercise
Optimal Nutrition
LifePak and Tegreen 97
Dietary Supplements
Cortitrol, LifePak and Tegreen 97

20. Common Anti-Stress Solutions
Valerian
Kava Kava
Melatonin
Tyrosine
None of these supplements directly address cortisol control

21. Cortitrol What is Cortitrol?
Enhances feelings of well-being and control in response to difficult situations
Improves performance and increased vigour throughout the day
Generates better mental concentration and focus
Supports weight maintenance efforts

22. Cortitrol: Advantage
Unique patent-pending dietary supplement that supports healthy cortisol levels
Proprietary (company owned) blend & comprehensive ingredients
Balances cortisol levels
Contains a proprietary, all-natural form of theanine extract
Manufactured according to the highest TGA standards and the Pharmanex 6S Quality Process

23. Cortitrol: Proprietary Formula
Comprehensive, proprietary formula that addresses direct cortisol modulation
Scientifically validated ingredients in clinically significant dosages
Magnolia Bark
Phosphatidylserine
Epimedium
L-Theanine

24. Cortitrol: Product Positioning
Tegreen 97
Antioxidant Protection
Joint Formula
Joint Health
BioGinkgo 27/7
Memory & Concentration
LifePak
Jungamals LifePak for Kids
General Health & Well-Being
Optimum Omega
Heart Health
FibreNet Plus
Digestive Health
Cortitrol
FibreNet
Digestive Health
Weight Management
OverDrive
Sports Nutrition
CordyMax Cs-4
Vitality & Stamina
Fatigue

25. OPTIMAL HEALTH FOUNDATION BLOCKS
FibreNet
Optimum Omega
Joint Formula
BioGinkgo 27/7
LifePak/
Cortitrol
Tegreen 97
OPTIMAL HEALTH FOUNDATION BLOCKS
Inner Health
Memory
Protection
Jungamals
LifePak for Kids

26. Cortitrol: Recommended Usage
Take two (2) tablets with your evening meal. For optimal results take an additional one (1) tablet with your morning meal

27. Cortitrol: And LifePak
Promote Cortitrol to be taken with LifePak.
Why?
Optimal nutritional health which includes vitamin C, B1, B2, Calcium, Magnesium, Pantothenic acid, and Pyridoxine, combined with cortisol modulation.

28. Cortitrol: Ingredients
Magnolia Bark
Phosphatidylserine
Epimedium
Theanine

29. Cortitrol: Product Support
Clinical Studies & references on individual ingredients in the formula
Pharmanex Web Site – or
PubMed Web Site -
Also on our web site:
Product Information
Q&As
Training Material
General Health Facts

30. Cortitrol: Q&A Why does Cortitrol come in tablet form?
Better cost value
Is there a difference b/w Epimedium brevicornum and koreanum?
No. Both are from two similar plants but have the same efficacy, the same active component. TGA preferred we use brevicornum.

31. Cortitrol: Q&A Are there any known drug interactions?
If you are pregnant or lactating, have a known medical condition or are taking a prescription medication, or are allergic to any component of this product, consult a physician prior to use.
Will coffee or caffeine negate the effectiveness of Cortitrol?
No, coffee or caffeine will not "negate" the effects of Cortitrol; rather, Cortitrol would be expected to permit the "energy" benefits of coffee but without the "jittery" side effects.

32. Cortitrol: Q&A
There are several hormones regarding stress besides cortisol. Why is Pharmanex focusing on cortisol and not the others?
Cortisol is the primary stress hormone. When we experience stress, cortisol is the stress hormone that remains elevated the longest.
Will Cortitrol make it hard for me to sleep at night?
In some cases, Cortitrol users have experienced increases in energy levels and makes them feel more alert. We suggest taking Cortitrol in the morning, rather than the evening, which seems to help.

33. Cortitrol: Q&A What is the normal range of cortisol levels?
The "normal" range for blood cortisol levels is fairly wide, 6-23 mcg/dl, but these levels can vary tremendously in response to stress, illness, and even following meals.

34. Cortitrol: Q&A Any drug or medical interactions?
We have found that people are able to take Cortitrol with most medications. Just like all of our products, however, we do not know all the potential interactions with Cortitrol. As always, we must recommend that they discuss this product with their doctor or pharmacist who knows their prescription history.
If you are pregnant or lactating, or taking a prescription medication, have a known medical condition, or allergic to any component of this product, please consult a physician prior to use. Consult a physician if you are taking prescription "anti-stress" medications such as anxiolytics, sedatives, or hypnotics. Consult a physician if you are taking other CNS depressants, tricyclic antidepressants, anti-epileptics, muscle relaxants, anticoagulants, corticosteroids and quinalone antibiotics. Use of l-theanine concomitantly with chemotherapeutic agents must be done under medical supervision. L-theanine may enhance the effects of doxorubicin, idarubicin, adriamycin, and picarubicin and may ameliorate some of their side effects (PDR for Nutritional Supplements 2001, Sadzuka 1996, Sugiyma 1998, 1999). This supplement should be discontinued two weeks prior to surgery.

35. Cortitrol: Marketing Material
Pharmanex Brochure (5 pk) $8.00
Pharmanex Cap (ea) $12.95
Power of Wisdom & Knowledge Video (ea) $7.50
Pharmanex Pill Box (ea) $3.00
Cortitrol Brochure (5 pk) $4.50
The Cortisol Story Brochure (5 pk) $9.50
Stress Test Card (5 pk) $11.00

36. Cortitrol Summary Balances cortisol levels
Proprietary blend of ingredients shown to have direct effects on cortisol levels
Proprietary l-theanine ingredient
Today’s answer to the fastest growing health demon!

37. Cortitrol Next Steps Order Today! Spread the word
Ensure all Distributors and Customers benefit from purchasing through ADP.