1. Energy and Metabolism
Chapter 6

2. Energy
The capacity to do work
Potential vs Kinetic

3. How is it measured? Heat Calorie Joule = 0.239 Calories
Most energy is provided by the sun

4. Oxidation-reduction reactions
AKA redox
OilRig

5. Thermodynamics Energy changes First Law of Thermodynamics
Second Law of Thermodynamics
How does this apply to humans?

6. Free Energy The energy Available to do work Delta G= Delta H- TDelta S
H= enthalpy which is the energy contained in the chemical bonds of a substance
T= temperature kelvin
S= entropy or the energy unavailable due to disorder

7. Endergonic vs Exergonic
If Positive Delta G then the reaction is endergonic
If Negative Delta G then the reaction is evergonic

8. Activation Energy
Spontaneous Chemical Reactions Require activation energy
Catalysts

9. You down with ATP???? The energy currency of cells
Hydrolysis drives endergonic reactions
ATP cycles continously

10. Enzymes Biological Catalysts Ligand vs Substrate Active Sites
Are they all proteins?

11. MultiEnzyme Complex Sounds familiar…. 3 advantages
Increases the frequency with which the enzyme collides with the substrate
Eliminates the possibility of unwanted reactions
All reactions take place within the complex can be controlled as a unit

13. Factors Affecting Enzyme Function
Temperature pH
Inhibitors and Activators
Allosteric Site
Cofactors

14. Inhibitors and Activators

15. Cofactors and Conenzymes
Assists enzyme function
Cofactors are usually metal ions
Coenzyme- a nonprotein organic molecule- can serve as an electron acceptor in a redox reaction

16. Metabolism Anabolic- use energy Catabolic- need energy
Biochemical Pathways
Evolution of BP’s

17. Feedback Inhibition
Regulates Biochemical Pathways
Why Important?