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Food and Drug Interactions
Khalid A. Al-Madani, MPH, DSc Consultant In Clinical Nutrition & Vice Present of Saudi Society for Food and Nutrition
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Medications and Food Intake Drug Complications That
Alter Food Intake
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and Food Intake (Conti.)
Medications and Food Intake (Conti.) Medication That Alter Appetite
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Diet-Drug Interactions on Nutrient Absorption
and Absorption Medication Effects on Nutrient Absorption
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Diet-Drug Interactions and Absorption (Conti.)
Drug-nutrient binding
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Diet-Drug Interactions and Absorption (Conti.)
Altered acidity in the stomach
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Diet-Drug Interactions and Absorption (Conti.)
Stomach Emptying Rate
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Diet-Drug Interactions
and Metabolism An increase leads to a decrease in enzyme activity in drug concentration and effect AND A decrease leads to an increase
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Diet-Drug Interactions and Metabolism ( Conti.)
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Diet-Drug Interactions and Metabolism ( Conti.)
A New Concern - Grapefruit Can cause more of a drug to be absorbed from intestine – even toxic levels May cause a drug not to work
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Diet-Drug Interactions and Metabolism ( Conti.)
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Diet-Drug Interactions and Metabolism ( Conti.)
Vitamin K and Warfarin Keep intake of foods containing Vitamin K constant Vitamin K is high in spinach, kale, cauliflower, broccoli and other leafy greens Also don’t take Vitamin K supplement
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Diet-Drug Interactions
and Excretion Medication Effects on Nutrient Excretion
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Diet-Drug Interactions
and Excretion ( Conti.) Dietary Effects on Medication Excretion
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Diet-Drug Interactions
and Toxicity
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Diet-Drug Interactions
and Toxicity ( Conti.) MOA Inhibitors No beer, red wine No cheddar, brie, mozzarella cheese No beef or chicken liver, cured meats, caviar or dried fish
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Diet-Drug Interactions
and Toxicity ( Conti.)
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Conclusion Clinicians often overlook or fail to recognize diet-drug interactions, yet such interactions can raise health care costs and result in serious, and sometimes fatal, complications. With hundreds of diet-drug interactions known and more to be identified in the future, health care professionals must learn to take steps to prevent them.
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