1. The New Kidney Allocation System: What Referring Physicians Need to Know The OPTN presents: The New Kidney Allocation System: What Referring Physicians Need to Know

2.  Explain the new kidney allocation policy and its goals  Summarize basic changes in allocation components for deceased donor kidneys  Describe patient indicators appropriate for transplant evaluation referral  List resources for additional information including education of patients Objectives

3. Richard Formica, Jr., MD Associate Professor of Medicine & Surgery Yale University School of Medicine

4.  Current Limitations o High kidney discard rates o Variability in access to transplant o Unrealized graft years o Unnecessarily high re-transplant rates Why change kidney allocation?

5.  Approximately 8,000 additional life years gained annually  Improved access for: o highly sensitized candidates o ethnic minority candidates  Comparable levels of kidney transplants at regional/national levels Predicted outcomes of the change

6. Major allocation components Replace SCD/ECD with KDPIIncorporate A 2 /A 2 B to B Add longevity matchingBase pediatric priority on KDPI Increase priority for sensitized candidates/CPRA sliding scale Remove payback system Include pre-registration dialysis timeRemove variances

7. Implementation Phase IPhase II Data updates required New reports released Calculators made available New allocation rules applied Variances turned off Payback system turned off Anticipated mid 2014Anticipated end 2014

8. Importance of early referral Pre-emptive listing Accrue Waiting Time with GFR <=20ml/min Receive 0-ABDR mismatch offers Sensitized candidates receive additional priority Identify issues that may complicate /prevent transplant Waiting time accumulates while issues are addressed Slowly progressive renal diseases could receive pre- emptive transplant

9. Revised waiting time calculation Current New Reminder Waiting time begins at/after registration with GFR <=20 ml/min OR On Dialysis Waiting time points awarded for dialysis prior to registration (pediatric and adults) Recognizes time spent with ESRD as basis for priority Waiting time points based on GFR remains the same

10. Sequence ASequence BSequence CSequence D Highly Sensitized 0-ABDRmm (top 20% EPTS) Prior living donor Local pediatrics Local top 20% EPTS 0-ABDRmm (all) Local (all) Regional pediatrics Regional (top 20%) Regional (all) National pediatrics National (top 20%) National (all) Highly Sensitized 0-ABDRmm Prior living donor Local pediatrics Local adults Regional pediatrics Regional adults National pediatrics National adults Highly Sensitized 0-ABDRmm Prior living donor Local Regional National Highly Sensitized 0-ABDRmm Local + Regional National 0-ABDR Mismatch Priority

11. Sensitized candidates Current New CPRA >=80% receive 4 additional points and zero points for moderately sensitized candidates Points assigned based on a sliding scale starting at CPRA>=20%

12. Point changes: Sensitization 0 00 0.08 0.21 0.34 0.48 0.81 1.09 1.58 2.46 4.05 6.71 10.82 12.17 17.30 0 2 4 6 8 10 12 14 16 18 20 0102030405060708090100 Points CPRA CPRA Sliding Scale (Allocation Points) (CPRA<98%) New Current

13. Sequence ASequence BSequence CSequence D Highly Sensitized 0-ABDRmm (top 20% EPTS) Prior living donor Local pediatrics Local top 20% EPTS 0-ABDRmm (all) Local (all) Regional pediatrics Regional (top 20%) Regional (all) National pediatrics National (top 20%) National (all) Highly Sensitized 0-ABDRmm Prior living donor Local pediatrics Local adults Regional pediatrics Regional adults National pediatrics National adults Highly Sensitized 0-ABDRmm Prior living donor Local Regional National Highly Sensitized 0-ABDRmm Local + Regional National New categories for highly sensitized candidates

14. Meelie DebRoy, MD Associate Professor of Surgery Rutgers Robert Wood Johnson Medical School

15.  There is no established system to ensure that medically appropriate candidates are referred for transplantation Early referral

16.  Patients with chronic kidney disease (Stage 3 or higher) or ESRD should be referred for transplant evaluation Guidance on early referral

17.  Pre-emptive transplant and timely, early referral is the goal o GFR range = 25-30  Education about transplant must begin before ESRD to be most effective o Stage 3-4 CKD  Begin discussing the importance of living donors  Initiate weight loss and smoking cessation counseling as necessary Guidance on early referral

18. Kidney Allocation System Communication, Education, and Resources

19.  Kidney Allocation Toolkit  FAQs  Sample messaging for discussing changes with patients  Patient brochure  Guidance for early referral considerations Subscribe to RSS feeds and a monthly newsletter http://transplantpro.org/kidney-allocation-system/ Resources for professionals

20. OPTN web site - http://optn.transplant.hrsa.gov UNOS web site* - http://www.unos.org Transplant Living* - http://www.transplantliving.org Transplant Pro* - http://transplantpro.org *These are a service of United Network for Organ Sharing and are not produced under the OPTN contract. More information