1. Bio-organic molecules 1. carbohydrates 2. proteins 3. lipids 4. nucleic acids

49. Protein function based on gene analysis Dr. Mani Subramanian; Celera Genomics NYTimes 2_14_01

51. Somatic cells are diploid

52. Chromosome 4 http://www.ncbi.nlm.nih.gov/cgi-bin/SCIENCE96/chr?4 Huntington’s Disease autosomal dominant Ellis van Creveld Syndrome autosomal recessive

56. DNA protein

57. Transcription

64. Translation

76. Protein binding 1. specificity 2. affinity 3. saturation 4. competition

86. A + B C + D

87. + 7 kcal/mol + H +

89. Energy is stored in chemical bonds

98. Enzyme substrate interactions 1. specificity 2. affinity 3. saturation 4. competition

100. M.R. Redinbo et al. (1998) Science 279: 1504 Enzyme: Topoisomerase I

104. Reaction rates What happens when you increase the amount of enzyme? What happens when you increase the amount of substrate?