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Published byJustus Lapham Modified over 10 years ago
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LICHEN PLANUS LICHEN PLANUS BY DR.MAHESH MATHUR, MD,DVD,DCP(UK)
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LICHEN PLANUS DIFINETION CHRINIC INFLAMMATORY DISEASE OF UNKNOW ETIOLOGY CHARECTRISED BY ------ SHINY VIOLACEOUS ITCHY FLAT TOPPED PAPULAR LESIONS MORPHOLOGICALLY & HISTOLOGICALLY CHARECTERISED BY -------- LIQUIFIED DEGENRATION OF BASAL CELL LAYER AND BAND LIKE LINEAR CELLULAR INFILTRATION IN DERMIS
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INCIDENCE WORLD WIDE – MUCH MORE IN ASIAN COUNTRIES 1 TO 2 % OF ALL NEW CASES IN DERMATOLOGY CLINIC SKIN LESION SUBSIDES IN 50 % OF CASES IN 9 MONTHS AND 100% BY 18 MONTHS MUCOUS MEMBREANS INVOLVE IN 30 OT 70 % CASES NAIL INVOLMENT IN 10% OF CASES
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PATHOGENESIS AUTOIMMUNE – INFILTRATION OF CD 4+ / CD 8+CELLS & INCREAS IN Langerhan’S CELLS NUMBER IN SKIN LESIONS FAMILIAL- HLA B7 -
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CLINICAL TYPES HYPERTROPHICUS FOLLICULAR ACTINICUS PIGMENTOSUS ANULAR LINEAR GUTTATE NAIL- 15% MUCOSAL- 40 TO 60% ORAL PERIANAL ESOPHAGIAL GENITAL
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TYPICAL LICHEN PLANUS
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SHINY, VIOLACEOUS PAPULAR LESIONS
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KOBNER’S PHENOMENON
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WICHAM’S STRAIE
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LICHEN PLANUS HYPERTROPHICUS
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LICHEN PLANUS - BULLOSUS
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BULLOUS LICHEN PLANUS
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LICHEN PLANUS
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ANNULAR LESION AT SHAFT OF PENIS
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LICHEN PLANUS ACTINICUS
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LICHEN PLANUS TROPICUS
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LICHEN PLANOPILARIS
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CICATRICAL ALOPECIA
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LICHEN PLANS AT PALM
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LICHEN PLANUS AT FOOT
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LICHEN PLANUS-ORAL LESION
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ORAL LICHEN PLANUS
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LICHEN PLANUS AT TONGUE
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LICHEN PLANUS -TONGUE
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EROSIVE LICHEN PLANUS
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PERI ANAL LICHEN PLANUS
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LICHEN PLANUS – PERIANAL REGION
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NAIL CHANGES IN LICHEN PLANUS
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LICHEN PLANUS- NAILS
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HISTOPATHOLOGY HYPERKERATOSIS HYPERGRANULOSIS ACANTHOSIS LIQUFYING DEGENERATION OF BASAL CELL LAYER EOSINOPHILIC CYTOID BODIES
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HISTOPATHOLOGY HIGH MAGNIFICAITON
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LICHEN PLANOPILARIS
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IMMUNOFLOURACENCE IgG & C3 DEPOSITION AT DERMOEPIDERMAL JUNCTION
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IMMUNOFLOURACENCE CYTOID BODIES IGM STAINING
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DRUGS CASUUSING LICHENOID REACTION ANTIMALARIALS THIAZID DIURATICS ISONIAZID CHLORPROPAMID B-BLOCKERS KETOCONAZOLE NSADS ACE INHIBITORS TETRACYCLINE COLOURING AGENTS
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LICHENOID DRUG RASH
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TREATMENT & PROGNOSIS STEROIDS-TOPICAL & SYSTAMIC PUVA CYCLOSPOIN AZOTHIOPRIN
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