1. Course directors: Profs. Arpad Somogyi, Sandor Szabo & Yvette Tache Chairs of Local Organizing Committee: Profs. Predrag Sikiric & Sven Seiwerth Main topics, with interactive presentations: The origins of stress concept & the seminal discoveries of Hans Selye What is stress, what is not Distress vs. eustress- similarities in the adrenal glands, differences in the brain The neuroendocrine mechanisms of stress;physiol.& pharmacol. of glucocorticoids Effect of stress on immune response & its role in the mechanisms of diseases Stress & structural GI diseases & functional GI disorders Other organ systems involved in biologic stress Management strategies : Pharmacologic interventions and/or life style changes My good & bad experience with stress: Challenges & lessons learned (Short, oral or poster presentations by registered attendees) Stress in our daily lives – Open forum with participation of all attendees STRESS: COMPREHENSIVE & AUTHENTIC SUMMER SCHOOL Selye International Institute for Advanced Studies & IUPHAR GI Section University of Zagreb, Faculty of Medicine, Departments of Pharmacology & Pathology July 21-25, 2014, Zagreb, Croatia Contacts: Scientific & professional issues: Sandor Szabo, MD, PhD, MPH szs@selyeinstitute.org szs@selyeinstitute.org Registration, lodging & local accommodations: Jelena Suran, DVM, PhD jelena.suran@gmail.comjelena.suran@gmail.com Registration fee: 150 € for undergraduate students 200 € for PhD students 300 € for others

2. STRESS: COMPREHENSIVE & AUTHENTIC SUMMER SCHOOL Selye International Institute for Advanced Studies & IUPHAR GI Section University of Zagreb, Faculty of Medicine, Departments of Pharmacology & Pathology July 21-25, 2014, Zagreb, Croatia The venue: Zagreb, capital of Croatia, is historic city with great cultural heritage (similar to Budapest, Prague & Vienna, each about 200-400 km from Zagreb). University of Zagreb, Faculty of Medicine is the oldest & best school of higher education in Croatia: in addition to historic buildings, it has modern lecture rooms & new student dormitory on its large, green campus (rooms available for 20-27 euros). Our special prices for hotel rooms in Zagreb are 100-150 euros. Course goals: To better understand the concept of biologic stress, its manifestations, mechanisms & its pharmacologic ramifications (e.g., the anti-inflammatory & immune-modulating actions of glucocorticoids & the possibility of drug-interventions in severe distress).

3. Welcome to Zagreb, the capital city of the Republic of Croatia. Zagreb is an old Central European city. For centuries it has been a focal point of culture and science, and now of commerce and industry as well. It lies on the intersection of important routes between the Adriatic coast and Central Europe. Zagreb is the hub of the business, academic, cultural, artistic and sporting worlds in Croatia. Zagreb can offer its visitors the Baroque atmosphere of the Upper Town, picturesque open-air markets, diverse shopping facilities, an abundant selection of crafts and a choice vernacular cuisine. STRESS: COMPREHENSIVE & AUTHENTIC SUMMER SCHOOL Selye International Institute for Advanced Studies & IUPHAR GI Section University of Zagreb, Faculty of Medicine, Departments of Pharmacology & Pathology July 21-25, 2014, Zagreb, Croatia