1. 1 CPCRN Mission To accelerate the adoption of evidence- based cancer prevention and control in communities.

2. 2 CDC/NCI Interagency Collaboration Dissemination –Joint interest CDC/NCI (Application/Research) –Complimentary strengths Shared interest in cancer Shared vision of CDC and NCI –Cancer care in the United States needs to improve. –Our investment in research needs to affect practice

3. 3 Changes at NCI Welcome a new team leader –Russ Glasgow PhD Continue the same team –Cynthia Vinson –Michael Sanchez Continue the same emphasis –Turning your vision 90 0 to your work Measuring & understanding the dissemination process

4. 4 What we expect of you Short term products –At least one all site project Progress in your own projects –Active working groups to achieve the goals –Consider the SIP announcement FQHC, connection to Comprehensive Cancer Use of existing cancer control resources (Planet) Intellectual power –Synthesis/integration/evaluation Progress in the measurement of dissemination Expanded collaboration –I’ll welcome you at NCI

5. 5 I’m on to Other work Two big initiatives on the horizon –Multilevel interventions –Population Registries Opitmizing Screening through Personalized Regimens (PROSPR)

6. Multilevel Interventions in Health Care: Building the Foundation for Future Research NCI Team Stephen Taplin, MD MPH, Steve Clauser PhD Rebecca Anhang Price PhD, Erica Breslau PhD, Veronica Chollette MS RN, Heather Edwards PhD, Irene Prabhu Das PhD External Consultants Arny Kaluzny PhD Martin Charns PhD, Maria Fernandez Phd, Mary Fennel PhD, Ernie Hawk MD, Tom Vogt MD, Jane Zapka ScD

7. Health care is a process affected by multiple contextual influences

8. We need to conduct research that evaluates these effects Traditional focus – Individual/family – Individual/physician – Effects of context on individual behavior Little examination of interactions among contextual influences Little examination of interventions that affect multiple levels (e.g. 3 or more)

9. Conference on the Horizon Multilevel Interventions in Health Care: Building the Foundation for Future Research – March 4-5, 2011, in Las Vegas, NV – Guided by an external consulting committee JNCI supplement – 11 Papers that grew out a June 2009 meeting Focus on factors affecting implementation – Contextual influences

10. Focus on Research Translation and Implementation Discoveries (e.g. genetic risk factor) Candidate Application (e.g. test) Practice & Control Programs in Communities Reducing the Burden of Disease in Communities T1: Epi, Cohorts, Biobanks Evidence based Guideline/ Policy T2: Clinical studies, RCTs T3: Implementation Research T4: Outcomes Research Adapted from Khoury et al; Gen Med 2007 Trials Phase I Phase II Phase III Phase IV PROSPR

11. PROSPR Objectives  Primary  Study the comparative effectiveness and outcomes of existing and emerging cancer screening processes  Breast  Colon  Cervical cancer.  Study the balance of benefits and harms of cancer screening across recognized cancer risk levels  Secondary  Share data and conduct preliminary studies relevant to future innovative research to optimize the screening process.  75 million over 5 years  9-12 sites, 1 statistical coordinating center National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health

12. Thanks It has been my pleasure and my privilege to work with you You are in good hands