1. A B C 0 50 100 150 200 FBG (mg/dl) ** PPAR  2 LacZ IB: PPAR  WAT Weight (g) 0 0.1 0.2 0.3 0.4 0.5 ** Body Weight Change (g) * 0 0.5 1.0 1.5 Uno et al. Figure S1 DE * Renin mRNA 0 0.5 1.0 1.5 AGT mRNA * 0.5 1.0 1.5 0

2. KK KK-Ay 0 10 20 30 40 50 N S Body Weight (g) Uno et al. Figure S2

3. S100 CGRP vehicle capsaicin Uno et al. Figure S3

4. S100 CGRP vehiclecapsaicin Uno et al. Figure S4

5. WAT Weight (g) 0 0.1 0.2 0.3 0.4 N S 0 0.1 0.2 0.3 Uno et al. Figure S5

6. F D WAT weight (g) 0 0.1 0.2 0.3 0.4 ** A Fsp27 mRNA PPAR  2 LacZ C FAS mRNA 0 1 2 3 ** B SREBP1c mRNA E UCP1 mRNA * 0 1 2 * 0 1 2 Uno et al. Figure S6 G * 0 1 1.5 0.5 Renin mRNA FBG (mg/dl) 0 50 100 150 200 ** 0 50 100 150

7. Fsp27 mRNA KK-AyKK 0 1 2 3 4 ** DIONC ** 0 5 10 15 Uno et al. Figure S7