1. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center The Research Institute at Nationwide Children’s Hospital Dave Billiter, MBA, PMP Director-Research Informatics Core

2. ………………..…………………………………………………………………………………………………………………………………….. Agenda

3. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center

4. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center Biobanking Biospecimen processing (procurement, testing, distribution, QA) Informatics (data collection and distribution, biospecimen inventory, virtual microscopy, interactions with SDC and CG disease committees ) Regulatory issues (CAP/CLIA certifications, MTA, informed consents, HIPAA) Interactions with the Cooperative Group structure (SDC, Disease committees, Group Chair) Disaster recovery initiatives (biospecimens, data) Personnel (PhDs, MDs, MBAs, histotechnologist, medical technologists, biomedical engineers, computer scientists, electrical engineers, college students, sponsor project officers)

5. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center Central receiving –Specimens received (from >500 national and international institutions): fresh, frozen, FFPE, formalin fixed, blood, blood products, bone marrow, urine COG: 88 protocols (open and closed) GOG: 50 protocols (open and closed) –Receive Federal Express shipments Monday through Saturday 70 to 100 packages a day (>1,000 biospecimens

6. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center COG institutions submitting specimens to the COG Bank 2003 and June 30, 2009

7. ………………..…………………………………………………………………………………………………………………………………….. Biopathology Center

8. ………………..…………………………………………………………………………………………………………………………………….. End Goal

9. ………………..……………………………………………………………………………………………………………………………………..

12. Workflows/Data Flows

13. ………………..…………………………………………………………………………………………………………………………………….. Data Dictionaries

14. ………………..……………………………………………………………………………………………………………………………………..

18. Current Solutions

19. ………………..……………………………………………………………………………………………………………………………………..

23. Recommendations Utilities/Tools focused on Non-Informatics/IT -Ex. CDE Mapper (UI) -Ex. Templates (.xls) Refactor CDE Browser (User-Friendly) -Ex. Ajax/JSON functionality EDUCATION and OUTREACH!

24. ………………..…………………………………………………………………………………………………………………………………….. THANK YOU!