1. This project was funded by the National Institute for Health Research Health Technology Assessment (NIHR HTA) Programme (project number 06/301/233) and will be published in full in Health Technology Assessment. The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA programme, NIHR, NHS or the Department of Health ACST-2 Recruitment Update Steffi le Conte- Trial Manager Luisa Teixeira- Recruitment Co-ordinator

2. ACST-2 recruitment to date… ACST-2 recruitment to date:1576

3. ACST-2 recruitment update… 102 active centres across 27 countries 246 patients already recruited so far in 2014 – With an average of 28 patients per month Highest recruitment month ever in the trial: – March 2014 with 43 patients! Best ever summer months of recruiting: – July: 30 patients – August: 24 patients

4. Cumulative recruitment Please visit the ACST-2 website to view each centre’s individual recruitment

6. 11 newly activated centres in 2014: Centre Name No. of Patients Country Activation Date Novosibirsk Research Institute of Circulation Pathology20Russia 27.02.2014 East Tallinn Central Hospital9Estonia 01.01.2014 Universitatsklinikum Hamburg-Eppendorf3Germany 04.02.2014 Stadtisches Klinikum Karlsruhe3Germany 11.02.2014 Department of Vascular Surgery, Attikon University Hospital2Greece 04.02.2014 Klinikum rechts der Isar derTechnischen Universität Muenchen2Germany 20.05.2014 Vascular Unit, 3rd Surgical Dept., Attikon University Hospital1Greece 30.04.2014 Ospedale San Francesco di Nuoro0Italy 21.02.2014 San Giacomo Hospital (Sardinia)0Italy 04.04.2014 Great Western Hospital (Swindon)0UK 20.05.2014 Unita Operativa Complessa di Cardiologia (Mirano)0Italy 17.09.2014

7. Centres recruiting their first patient in 2014: Regional Hospital Liberec (Czech Republic) Regional Specialist Hospital Wroclaw (Poland) Rijnstate Hospital (The Netherlands) San Camillo Forlanini Hospital (Italy) Semmelweis Medical University (Hungary) Sendai Medical Centre (Japan)

8. Assisting you… New Training Initiative New Qualitative Recruitment Investigation (QRI) Recruitment Tips document – Please find a copy of the tips document in your welcome pack

9. Going forward… Target : 2000 patients recruited by end of 2019 Monthly recruitment for ACST-2 needs to be: (or more!) We will work together with you on this… – Individual centres have different approaches

10. Please keep on recruiting! Please visit the new ACST-2 website: www.acst.org.uk – Your centres’ recruitment – Your photos – Your presentations – ACST-2 news

11. Thank you! Tel: 0044 1865 221 345 | e-mail: acst@nds.ox.ac.ukacst@nds.ox.ac.uk Visit: www.acst.org.uk for more informationwww.acst.org.uk ACST-2 is looking for new, high-recruiting centres to be involved. If you know them, please tell us!