1. PHC 222 Part(I) Dr. Huda Al Salem Lecture (4)

2. Factors that affect the affinity 3- Stereochemistry of the drug

3. Example 1: Acetylcholine

4. 3- Stereochemistry of the drug Conformation is the spatial arrangement of atoms in a molecule that comes from free rotation of atoms around a single chemical bond. Requirement: It occurs without breaking bonds.. Configuration is the spatial arrangement of bonds in a molecule in a permanent geometry. Requirement: can be changed only by breaking bonds

5. 3- Stereochemistry of the drug A B C  C`  A`  C`  A`  B`

6. Example 2: Norephedrine

7. Example 3: Labetalol