1. The Complement Cascade The Terminal Pathway

2. Complement: The Terminal Pathway C3b C3b is the first component of the Terminal Pathway C3a C3

3. Complement: The Terminal Pathway C5 C3b C3b cleaves C5 C5b C5a producing C5a and C5b Next

4. Complement: The Terminal Pathway C6 C5b binds to C6 C5b

5. Complement: The Terminal Pathway C5b binds to C6 Next C5b.6

6. Complement: The Terminal Pathway C7 C5b.6 binds to C7 C5b.6

7. Complement: The Terminal Pathway C5b.6 binds to C7 Next C5b.6.7

8. Complement: The Terminal Pathway C8 C5b.6.7 binds to C8 C5b.6.7

9. Complement: The Terminal Pathway C5b.6.7 binds to C8 Next C5b.6.7.8

10. Complement: The Terminal Pathway C5b.6.7.8 C9 C5b.6.7.8 binds 12-15 molecules of C9 to form the Membrane Attack Complex C9

11. Complement: The Terminal Pathway C5b.6.7.8.9n C5b.6.7.8 binds 12-15 molecules of C9 to form the Membrane Attack Complex Next

12. Complement: The Terminal Pathway  The following slides are a graphical illustration of the terminal pathway  The end-point is the formation of the membrane attack complex which punches a hole in the bacterial membrane.  This loss of membrane integrity results in the death of the bacteria The graphics run automatically Next

13. Complement: The Terminal Pathway pathogen cell membrane

14. Complement: The Terminal Pathway C5b

15. Complement: The Terminal Pathway C6

16. Complement: The Terminal Pathway C7

17. Complement: The Terminal Pathway

18. C8

19. Complement: The Terminal Pathway C9

20. Complement: The Terminal Pathway

33. The Membrane Attack Complex End of Presentation