1. The Department of Biochemistry of Medical Faculty Presents now Edited by Attila Sandor SYNTHESIS of CHOLESTEROL and KETONE BODIES

2. Classification of lipids on chemical basis Fatty acid derivativesIsoprenoids Simple lipidsComplex lipids Triglycerids Vaxes Phospholipids Glycolipids Steroids Carotinoids Author`s picture

3. A C5 hydrocarbon occurring in oil but not in living organisms Lehn. 4 th ed., p.816

4. The way of isoprenoid synthesis (1) an enzyme of  -oxidation C2+C2 = C4

5. The way of isoprenoid synthesis (2) C4+C2 = C6

6. The way of isoprenoid synthesis (3) to ketone bodies C6

7. C6-C=C5 C6 The way of isoprenoid synthesis (4) Formation of the final C5 unit

8. The action of C15 prenyltransferase (3 X 5) C5 C15 C10

9. The action of C15 squalene synthase (2 X 15)

10. Strayer 5 th ed. 26.10, p724 Formation of Squalene (2 X 15 = 30), still straight skeleton Head to Head

11. Cholesterol -3C Cholesterol C27 -3C

12. (6C X 5C)-3C = 27C, ring 17C + 2C methyl + 8C side chain Structure, nubering and origins of atoms of cholesterol Strayer, 5 th ed. 26.25 p.733

14. Chlesterol may be esterified with fatty acids Lehn., 4 th ed. Fig. 21-38, p.820

15. polyprenyltransferase C15 prenyltransferase C20 prenyltransferase Compounds built from C5 isoprenoid blocks Lehn., 4th ed. Fig. 21-48, p.828

16. The way of isoprenoid synthesis (3) to ketone bodies C6

17. HMG-CoA is a branchpoint Cleavage enzyme Reductase HMG-CoA synthase Ketone bodies Cholesterol Strayer, 5 th ed. 26.7 p.723

19. The two ketone bodies are interchangable

20. The activation of acetoacetate for the metabolism

21. THANK YOU FOR YOUR ATTENTION The honored audience has the opportunity now to download the pictures of this lecture Attila Sandor from here or from the intranet: CholesterolKetoneBodies.ppt