1. Recent progress in the Total Synthesis of typical lignans Pusheng Wang 2012-11-10

2. Ligin ( 木质素 ) and Lignan ( 木酯素 ) 2 木质素（ Ligin ）是由四种醇单体（对香豆醇、 松柏醇、 5- 羟基松柏醇、芥子醇）形成的一 种复杂酚类聚合物。 木脂素（ Lignan ）是一类由两分子苯丙素衍 生物（即 C6-C3 单体）聚合而成的天然化合 物，多数呈游离状态，少数与糖结合成苷而 存在于植物的木部和树脂中，故而得名。通 常所指其二聚体，少数可见三聚体、四聚体。

3. Total synthesis of typical ligans in recent years 3

4. Part A | (-)-Podophyllotoxin and (-)-Picropodophyllin David B. Berkowitz, J. Org. Chem. 2000, 65, 847-860 4

5. Part A | (−)-Sacidumlignans B and D C. V. Ramana, J. Org. Chem. 2012, 77, 1566-1571 5

6. Part B | (-)-talaumidin Yoshiyasu Fukuyama, Tetrahedron Lett. 2006, 47, 3979-3983 6

7. Part B | (+)-Chicanine Yoshiyasu Fukuyama, Tetrahedron Lett. 2011, 52, 3005-3008 7

8. Examination of the Mitsunobu etherification 8

9. Part B | (+)-veraguensin Subrata Ghosh, Tetrahedron Lett. 2010, 51, 6924-6927 9

10. Part B | (+)-virgatusin Jeffrey S. Johnson, Chem. Commun. 2009, 5135-5137 10

11. Part B | (+)-Magnolone Ganesh Pandey, Tetrahedron Lett. 2010, 51, 2975-2978 11

12. Part B | (+)-wikstromol Michael Sefkow, Tetrahedron: Asymmetry 2001, 12, 987-989 12

13. Part C | (+/-)-Paulownin Steven R. Angle, J. Org. Chem. 2008, 73, 6268-6278 13

14. Part C | (-)-Wodeshiol Oee Sook Park, J. Chem. Sci. 2011, 123, 327-330 14

15. Part D | Carpanone Craig W. Lindsley, Org. Lett. 2008, 10, 4097-4100 15

16. Part E | Dibenzocyclooctadiene Robert S. Coleman, J. Org. Chem. 2005, 70, 8932-8941 16

17. Part E | Eupomatilones Robert S. Coleman, Org. Lett. 2002, 6, 4025-4028 J. Org. Chem. 2007, 72, 8724-8736 17

18. Part E | Eupomatilones Robert S. Coleman, Org. Lett. 2002, 6, 4025-4028 18

19. Part E | Eupomatilones Robert S. Coleman, J. Org. Chem. 2007, 72, 8724-8736 19

20. Part E | (-)-Steganone Gary A. Molander, J. Am. Chem. Soc. 2000, 122, 52-57 20

21. Summary Main source of chirality: 21