1. Carotenoids and Lung Cancer Publication Männistö, S., et al. Dietary carotenoids and risk of lung cancer in a pooled analysis of seven cohort studies. Cancer Epidemiology, Biomarkers and Prevention, 2004; 13: 40-48.

2. Nurses’ Health Study Netherlands Cohort Study New York State Cohort Iowa Women’s Health Study Canadian National Breast Screening Study Alpha-Tocopherol Beta-Carotene Cancer Prevention Study Health Professionals Follow-up Study Cohort Studies Included in the Pooled Analysis of Carotenoids and Lung Cancer Total = 399,765 # cases = 3,155 Männistö, et al. 2004

3. Study Baseline # of Cohort Cases ATBC 6,771 298 Canadian National 56,837149 Health Professionals44,350244 Iowa Women’s 33,828433 Netherlands Cohort (W) 62,412131 Netherlands Cohort (M) 58,279843 New York State (W) 21,045130 New York State (M) 27,936392 Nurses’ Health (a) 88,307156 Nurses’ Health (b) 68,307379 Cohort Studies in the Pooled Analysis of Carotenoids and Lung Cancer Männistö, et al. 2004

4. Mean Carotenoid Intakes (mcg/d) Study Alpha- Beta- Beta- carotene carotene cryptoxanthin ATBC 527 1758 25 Canadian National 986 4619 79 Health Professionals 980 5159 88 Iowa Women’s 773 4527 74 Netherlands Cohort (W) 685 2901 206 Netherlands Cohort (M) 687 2960 155 New York State (W) 1144 6346 247 New York State (M) 1171 6382 215 Nurses’ Health (a) 723 4424 104 Nurses’ Health (b) 764 4273 62 Männistö, et al. 2004

5. Mean Carotenoid Intakes (mcg/d) (cont’d) Study Lutein/Lycopene Zeaxanthin ATBC 1146 645 Canadian National 3037 8891 Health Professionals 3949 10844 Iowa Women’s 2795 4180 Netherlands Cohort (W) 2448 1303 Netherlands Cohort (M) 2550 1045 New York State (W) 5998 5683 New York State (M) 6025 7274 Nurses’ Health (a) 5086 5255 Nurses’ Health (b) 3531 9643 Männistö, et al. 2004

6. Alpha- and Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Quintile Quintile Alpha- Beta- carotene carotene 1 1.00 1.00 2 0.91 (0.80-1.05) 0.97 (0.82-1.16) 3 0.94 (0.84-1.06) 1.00 (0.84-1.20) 4 0.95 (0.84-1.07) 0.94 (0.82-1.08) 5 0.93 (0.82-1.06) 0.98 (0.87-1.11) p for trend 0.47 0.47 p for het. for Q5 0.39 0.85 Männistö, et al. 2004

7. Lutein and Lycopene and Lung Cancer: Pooled Multivariate Relative Risks by Quintile Quintile Lutein/ Lycopene Zeaxanthin 1 1.00 1.00 2 0.98 (0.87-1.10) 0.86 (0.75-0.97) 3 0.92 (0.79-1.06) 0.85 (0.74-0.99) 4 0.97 (0.86-1.10) 0.88 (0.77-1.01) 5 0.91 (0.81-1.03) 0.91 (0.78-1.07) p for trend 0.15 0.42 p for het. for Q5 0.81 0.11 Männistö, et al. 2004

8. Beta-Cryptoxanthin and Lung Cancer: Pooled Relative Risks by Quintile Quintile Age-adjusted Multivariate 11.001.00 20.71 (0.64-0.80) 0.90 (0.80-1.00) 3 0.59 (0.51-0.69) 0.83 (0.71-0.96) 40.56 (0.48-0.64)0.86 (0.76-0.97) 50.50 (0.43-0.57) 0.76 (0.67-0.86) p for trend <0.001<0.001 p for het. for Q5 0.27 0.95 Männistö, et al. 2004

9. Pooled Multivariate Relative Risks for Lung Cancer by Categories of Beta-Cryptoxanthin Relative Risk Männistö, et al. 2004

10. Study-Specific Multivariate RRs (Quintile 5 vs. 1) for Beta-Cryptoxanthin and Lung Cancer Männistö, et al. 2004

11. Beta-Cryptoxanthin and Lung Cancer: Pooled Multivariate Relative Risks by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 0.74 0.80 0.84 3 0.79 0.93 0.87 4 0.77 0.84 0.70 (0.42-1.42) (0.69-1.03) (0.60-0.81) p for trend 0.80 0.43 <0.001 p for het. due to smoking status for Q4 = 0.30 Männistö, et al. 2004

12. Beta-Cryptoxanthin and Lung Cancer: Pooled Multivariate Relative Risks by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n=901 1 1.00 1.00 1.00 2 0.79 0.84 0.71 3 0.86 0.74 0.76 4 0.80 0.66 0.67 (0.68-0.93) (0.51-0.87) (0.56-0.80) p for trend 0.01 0.02 <0.001 p for common effects by cell type for Q4 = 0.24 Männistö, et al. 2004

13. Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Smoking Status Quartile Never Past Current n=259 n=981 n=1915 1 1.00 1.00 1.00 2 1.11 0.88 1.01 3 0.98 0.86 0.98 4 1.02 1.06 0.98 (0.70-1.47) (0.86-1.32) (0.84-1.14) p for trend 0.73 0.61 0.62 p for het. due to smoking status for Q4 = 0.83 Männistö, et al. 2004

14. Beta-Carotene and Lung Cancer: Pooled Multivariate Relative Risks by Cell Type Quartile Adeno. Small Squamous n=956 n=538 n=901 1 1.00 1.00 1.00 2 0.98 1.13 0.88 3 1.03 1.03 0.96 4 1.04 1.18 1.06 (0.85-1.27) (0.97-1.43) (0.89-1.27) p for trend 0.84 0.21 0.50 p for common effects by cell type for Q4 = 0.66 Männistö, et al. 2004