1. MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic Ganglionic Skeletal Muscle Neuronal CNS

2. MCMP 407 Receptors and signal transduction in the ANS: Nicotinic Receptors

3. MCMP 407 Receptors and signal transduction in the ANS: Nicotinic Receptors     

4. MCMP 407 Receptors and signal transduction in the ANS Cholinergic Receptors NicotinicMuscarinic M1M5M3M4M2

5. MCMP 407 Receptors and signal transduction in the ANS: Muscarinic receptors are 7 transmembrane domain, G-protein coupled receptors

6. MCMP 407 Receptors and signal transduction in the ANS: Muscarinic receptors (M 1, M 3, M 5 ) NH 3 COOH G q Phospho- lipase C (+) PIP 2 IP 3 Diacylglycerol Increase Ca 2+ Activate Protein KinaseC Response

7. MCMP 407 Receptors and signal transduction in the ANS: Muscarinic Receptors (M2 and M4)

8. MCMP 407 Receptors and signal transduction in the ANS Adrenergic Receptors  1A 11 22  1B  1D  2A  2B  2C 11 22 33

9. MCMP 407 Receptors and signal transduction in the ANS:  1 -Adrenergic Receptors

10. MCMP 407 Receptors and signal transduction in the ANS:  2 -Adrenergic Receptors

11. MCMP 407 Receptors and signal transduction in the ANS:  -Adrenergic Receptors

12. MCMP 407 Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Heart Rate of ContractionIncrease  1 DecreaseM 2 Force of ContractionIncrease  DecreaseM 2 Functional Responses Mediated by the ANS  1,1,

13. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Arteries (most)Vasoconstriction  1 ------------ VeinsVasoconstriction  2 ------------ Skeletal MuscleVasodilation  2 ------------ Endothelium------------Release EDRFM 3

14. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Lung Bronchiolar smooth muscle BronchodilationBronchoconstrictionM3M3  2

15. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Bladder wallRelaxation 22 ContractionM3M3 UreterContraction  1 RelaxationM3M3 SphincterContraction  1 RelaxationM3M3 Uterus (pregnant)Relaxation 22 Variable Penis/vas deferensEjaculation Genitourinary, smooth muscle Contraction M 3  1  1 M3M3 Erection

16. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Salivary GlandsIncrease secretion  1 Smooth Muscle: Relaxation  2,  2 M3M3 SphinctersContraction  1 RelaxationM3M3 Secretion------------Increase secretionM 3 Gastrointestinal Tract M 3 WallsContraction

17. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Hair follicles, Smooth muscle Contraction, Piloerection 11 ---------------- Sweat glands ThermoregulationIncrease secretion Skin -- -------------- M3M3 Increase secretion 11 Apocrine (stress) -- --------------

18. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor Iris Radial muscleContraction Eye -- -------------- 11 -------------Circular muscle M3M3 Contraction -- Ciliary muscle [Relaxation M3M3 Contraction 2]2] Ciliary epithelium Increase secretion of aqueous humor -- -------------- 22

19. MCMP 407 Physiology of the eye Lens Iris Radial muscle (  1 ) Circular muscle (M 3 ) Canal of Schlemm Trabecular meshwork Ciliary muscle (M 3 ) Ciliary epithelium (  2 )

20. MCMP 407 Physiology of the eye

21. MCMP 407 Physiology of the eye Pupil Circular muscle (M3 Receptors)

22. MCMP 407 Physiology of the eye Pupil Contraction of circular muscle leads to miosis

23. MCMP 407 Physiology of the eye Pupil Contraction of circular muscle leads to miosis

24. MCMP 407 Physiology of the eye Pupil Radial Muscle (  1 Receptors)

25. MCMP 407 Physiology of the eye Pupil Contraction of radial muscle leads to mydriasis

26. MCMP 407 Functional Responses Mediated by the ANS Effector Organ Adrenergic ResponseReceptor Cholinergic ResponseReceptor LiverGlycogenolysis---------------- Fat cellsLipolysis---------------- Kidney Increase renin secretion  1 ---------------- Pancreas Decrease insulin release Metabolic functions -- -------------- 1, 31, 3 22 Gluconeogenesis 1, 21, 2