1. 3 RD PRESENTATION

2. POTENTIAL PROBLEMS Dosing (restlessness, vomiting) Drug resistance by cancer cells

3. ALTERNATIVE APPROACH The maximum tolerated dose is set at 8 grams/m2 or 16 grams/day for period of four weeks in humans. Cancer cells might become resistant to limonene in future. Perillyl alcohol can be used to support limonene because it has a strong chemopreventive effect in cancer treatment and its invivo test shown no toxic effect in rats and have no toxic effect in humans. It is obtained from cherries and other fruits.

4. Feasibility Jessica A. Miller, Patricia A. Thompson, Iman A. Hakim, Ana Maria Lopez, Cynthia A. Thomson, Wade Chew, Sherry Chow (University of Arizona cancer research and Zuckerman college of public health) in March, 2012. was accepted in August, 2012 and Published in October,2012. They maintained a 16gram of limonene per day in four women with breast cancer for 4weeks. Result: they found out that limonene causes no toxic effect in humans and also causes huge reduction to cancer growth. They also found that limonene has great reduction effect at the early stage of cancer and tumor growth.

5. Conclusions: Since limonene causes no toxic effect in humans, and it can be supported with perillyl alcohol to increase its ability in cancer and tumor inhibition, I strongly proposed that limonene should be used in cancer therapy.

6. REFERENCES Jessica A. Miller, Patricia A. Thompson, Iman A. Hakim, Ana Maria Lopez, Cynthia A. Thomson, Wade Chew, Chiu-Hsieh Hsu, H.-H. Sherry Chow. Safety and feasibility of limonene, Journal of Cancer Therapy, 2012, 3, 749-754. Young Life Research Clinic.” Lmonene and Tumor”. Young Living Research. P.134. 18 Sept 2012. Web 26 Sept 2012. Arizona Cancer Center. “Cancer Research” N.P. May 2012. Web.