1. Hemorrhogic Fever Virus

2.  Hantaar Virus or HEMORRHAGIC FEVER with renal syndrome virus ( HFRS ）  Xing Jiang Hemorrhogic Fever Virus

3. Hantaar Virus ( HEMORRHAGIC FEVER with renal syndrome virus )

4. Morphology  Spherical, 80-120nm  Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L')  Envelope: 2 glycoproteins, G1 and G2,

6. Morphology

8. Biological properties 1. ssRNA with long, medium,short segments 2. Antigens 6 serotypes (I- VI) 3. Resistance: weak

9. Epidemiology 1. Natural host : rodents (deer mouse (Peromyscus maniculatus), cotton rat (Sigmodon hispidus), marsh rice rat (Oryzomys palustris), white-footed mouse (Peromyscus leucopus), other carriers) 2. Transmission : Droplet and rodent excreta spread 3. Season and district

10. Clinical syndromes  Headache;  Pink in face, neck  Fever  marked bleeding tendency  Lower blood pressure  Urine with Protein  multi-organ failure

11. Pathogenicity 1. Clinical manifestations: 5 phases  Fever phase  Hypotension phase  Auria phase  Polyuria phase  convalescent phase

12. Pathogenesis  Viral direct damage  Immunopathogenesis

13. Laboratory diagnosis  Cultivation: Vero-E6 cell and A549 cell  Serological diagnosis: IgM/IgG indirect immunofluorescent assay ELISA-IgM

14. Prevention and treatment  Inactivated vaccine

15. Xing Jiang Hemorrhogic Fever Virus

16. Morphology  Spherical, 80-120nm  Nucleocapsid: Helical, 3 segments, 2 proteins - nucleocapsid ('N'), RNA polymerase ('L')  Envelope: 2 glycoproteins, G1 and G2,

17. Vector and Host  Animal Host  Hyalomma asiaticum

18. Pathogenesis  Season: April and May

19. Prevention  Inactivated vaccine