1. Hélène Eltchaninoff CHU Rouen, France Symposium Edwards Valves Aortiques Hightech 2012 - MARSEILLE Le futur

2. Nouvelle technologie Etudes

3. 20mm* SAPIEN XT, disponible en 4 tailles SAPIEN XT THV* Hors USA Voies Transapicale et Transaortique Voie Transfémorale NovaFlex+ with eSheath Ascendra+* Annulus Size (mm) 23mm 26mm 29mm* Tailles 12/9/2011 Japan EU

4. …Expect CE Mark Trials on Two New Valve Platforms in 2012 12/9/2011 Balloon-Expandable

5. …Expect CE Mark Trials on Two New Valve Platforms in 2012 12/9/2011 Balloon Expandable Self-Expanding Balloon-Expandable

6. Edwards SAPIEN 3 Valve Ultra Low-Profile Balloon Expandable Platform SAPIEN 3 Valve Designed to further reduce PV leaks Lower profile valve : 14 Fr eSheath Discrete valve that anchors in the annulus Treated bovine pericardial tissue leaflets Dramatically reduced profile for the transapical approach 12/9/2011

7. Edwards CENTERA Valve CENTERA is Edwards’ First Self- Expanding Transcatheter Valve Motorized delivery system for stable deployment and single operator use Repositionable Delivered through a 14 Fr eSheath Discrete valve that anchors in the annulus Treated bovine pericardial tissue leaflets Transfemoral and subclavian approach 12/9/2011 Ultra Low-Profile Self Expanding Platform First-in-Man Experience Completed

8. Les études en cours et à venir PARTNER 2: Critère combiné décès + AVC 1) SAPIEN XT vs RVA STS < 4% 2) SAPIEN vs SAPIEN XT Pts inopérables USA PROTAVI-C: AVC et IRM (Embrella)