1. FcɛRI Signalling Pathway

2. The Ligand : IgE

3. Mast and Basophil Cells

5. Fc receptors bind tail region of IgE antibodies. Histamine, proteases,

6. The Receptor

7. Tyrosine Kinases Lyn Syk

8. The Pathway Binding of IgE Aggregation of receptors

9. Syk activationCascade of reactionsDegranulation Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor. Syk can also phosphorylate syk associated with adjacent receptor

10. Allergy sufferers are at a lower risk of developing cancer

11. Inverse association between IgE and malignancies IgE-mediated immune responses against tumor cells IgE-based treatment options

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18. Click to edit the outline text format Second Outline Level  Third Outline Level Fourth Outline Level  Fifth Outline Level  Sixth Outline Level  Seventh Outline Level  Eighth Outline Level  Ninth Outline Level Histogram not generating all first passage times

19. Click to edit the outline text format Second Outline Level  Third Outline Level Fourth Outline Level  Fifth Outline Level  Sixth Outline Level  Seventh Outline Level  Eighth Outline Level  Ninth Outline Level But it wasn't so bad Bngl easy to understand Easy to define chemical reactions Can manipulate molecule concentrations Can set time period of reaction