1. Physiology, Homeostasis, and Temperature Regulation29
Physiology, Homeostasis, and Temperature Regulation

2. Homeostasis such as temperature, pH, and ion concentration.
the maintenance of stable conditions in an internal environment.
Cells are specialized for maintaining the internal environment
such as temperature, pH, and ion concentration.
Specialized cells evolve into tissues, organs, and physiological systems that serve specific functions to maintain homeostasis

3. Multicellular organisms need a stable fluid environment
Concept 29.1 Multicellular Animals Require a Stable Internal Environment
Multicellular organisms need a stable fluid environment
Intracellular fluid – within the cells (mostly water)
extracellular fluid
which includes blood plasma and interstitial fluid that bathes each cell.
APPLY THE CONCEPT Multicellular animals have an internal environment of extracellular fluid

4. Figure 29.1 The Internal Environment

5. Four types of tissue: Epithelial Connective Nervous Muscle
Cells make up tissues
Four types of tissue:
Epithelial
Connective
Nervous
Muscle

6. Epithelial Tissue
are sheets of tightly connected epithelial cells that cover inner and outer body surfaces.
Some line blood vessels and hollow organs.
Some secrete substances such as hormones or sweat, or serve transport functions for nutrients.
Others serve sensory functions of smell, taste, and touch.

7. Connective Tissue
are dispersed cells in a secreted extracellular matrix.
The composition of the matrix differentiates the types of connective tissues.
Collagen and elastin provide strength and elasticity to cartilage.
Bone matrix is mineralized for strength while the matrix of blood cells—plasma—is liquid.
Adipose tissue, made of fat cells, has little matrix.

8. contain two basic cell types— neurons and glial cells.
Nervous Tissue
contain two basic cell types— neurons and glial cells.
Neurons generate and conduct electrical signals, or nerve impulses, throughout the body.
They are units of the central and peripheral nervous systems and communicate via chemicals, neurotransmitters.
Glial cells provide support for neuronal function.

9. consist of elongated cells that generate force and cause movement.
Muscle Tissues
consist of elongated cells that generate force and cause movement.
Three types of muscle tissues:
Skeletal—responsible for locomotion and movement
Cardiac—makes up the heart and generates heartbeat and blood flow
Smooth—involved in movement and generation of forces in internal organs

10. To maintain homeostasis:
Information
Control
Set point – a reference
Feedback – what is happening
Error Signal – any difference between set pt. and feedback
Negative Feedback
Positive Feedback
Feedforward Information
Regulation
Sensor
Effectors

11. Figure 29.3 Control, Regulation, and Feedback
Feed forward – changes set point!
Set point
feedback
Regulatory system

12. Obtain, integrate, and process information
Concept 29.2 Physiological Regulation Achieves Homeostasis of the Internal Environment
Regulatory systems:
Obtain, integrate, and process information
Issue commands to controlled systems
Contain sensors to provide feedback information that is compared to the set point
Regulatory systems then issue commands to effectors that effect changes in the internal environment.
Effectors are controlled systems because they are controlled by regulatory systems.

13. Sensory information in regulatory systems includes: Negative feedback
Concept 29.2 Physiological Regulation Achieves Homeostasis of the Internal Environment
Sensory information in regulatory systems includes:
Negative feedback
Positive feedback
Feedforward information

14. Stabilizes Negative feedback:
Concept 29.2 Physiological Regulation Achieves Homeostasis of the Internal Environment
Negative feedback:
Causes effectors to counteract the influence that creates an error signal
Results in a movement back to set point
Example: driving too fast – causes you to slow down!
Stabilizes

15. Reach limit, then terminate
Positive Feedback
Positive feedback:
Amplifies a response
Increases deviation from a set point
Examples: sexual behavior – little stimulation increases behavior response
Reach limit, then terminate

16. Feedforward Information
Anticipates internal changes and changes the set point.
Example: seeing deer changes set point to lower speed

17. 29.3 Living Systems are Temperature Sensitive

18. Concept 29.3 Living Systems Are Temperature-Sensitive
Physiological processes are temperature- sensitive and increase their rate at higher temperatures.
Q10 describes temperature-sensitivity as the quotient of the rate of a reaction at one temperature divided by the rate of the same reaction at a lower temperature (10 degrees)
Q10 = RT/RT–10

19. Figure 29.4 Q10 and Reaction Rate
Rxn rates are doubled
Or tripled as temp.
Increases by 10
=1, not temp. sensitive

20. if Q10 < 1 the rate drops with an increase in T if Q10 > 1 then the rx rate increases with temperature

21. Calculate the Q10 for the following scenario
A rate of an enzyme worked at a rate of 76 at 10 degrees Celsius and it worked at a rate of 145 at 20 degrees Celsius.
145/76 = (the exponent cancels out 10/(20-10)
The temperature for these calculations do NOT always have to be 10 apart. See formula.

22. Animals can acclimatize to seasonal temperature changes
Animals can regulate their body temperature
Ectotherms – depends on temperature of environment
Endotherms – maintain constant body temperature independent of external temperatures

23. Figure 29.5 Ectotherms and Endotherms React Differently to Environmental Temperatures (Part 1)

24. Figure 29.5 Ectotherms and Endotherms React Differently to Environmental Temperatures (Part 2)
In the thermoneutral zone the metabolic rate is low and independent of temperature.
The basal metabolic rate (BMR) is the metabolic rate of a resting animal at a temperature within the thermoneutral zone.

25. Concept 29.4
Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
Metabolism—conversion of ATP to do work produces heat
Radiation—warmer objects lose heat to cooler objects by radiation
Convection—heat is lost when wind is cooler than body surface temperature
Conduction—heat is transferred when objects of different temperatures come into contact
Evaporation—heat is lost and body is cooled when water leaves the body

26. expend most of their energy pumping ions across membranes.
Mammals and Birds (Endotherms) have high rates of metabolic heat production
expend most of their energy pumping ions across membranes.
Cells are “leakier” to ions than cells of ectotherms.
Endotherms spend more energy and release more heat to maintain ion concentration gradients.
LINK Review the mechanisms of ion transport described in Concepts 5.2 and 5.3

27. Mammals produce heat in two ways:
Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
If environmental temperature (Ta) falls below an endotherm’s lower critical temperature, animal must produce heat or body temperature (Tb) will fall.
Mammals produce heat in two ways:
Shivering —skeletal muscles contract and release energy from ATP as heat.
Nonshivering heat production—in adipose tissue called brown fat. –
*hibernation
See Chapter 6, p. 104

28. Brown fat has lots of mitochondria and a rich blood supply!
Figure Brown Fat
Brown fat has lots of mitochondria and a rich blood supply!

29. The BMR per gram of tissue increases as animals get smaller.
Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
The basal metabolic rate (BMR) is correlated with body size and environmental temperature.
The BMR per gram of tissue increases as animals get smaller.
Example: A gram of mouse tissue uses energy at a rate 20 times greater than a gram of elephant tissue.

30. Reducing heat loss is important in cold climates.
Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
Reducing heat loss is important in cold climates.
Some cold-climate species have a smaller surface area than warm-climate relatives.
Rounder body shapes and shorter appendages reduce surface area-to- volume ratios.

31. Figure 29.9 Anatomical Adaptations to Climate (Part 1)
Short Fur
Limited body insulation
Large ears and long limbs allow heat to radiate out

32. Figure 29.9 Anatomical Adaptations to Climate (Part 2)
Thick coat of insulating fur
Small ears, short limbs, rounded body shape give it a smaller surface area to volume ratio – so less heat can be lost

33. Other adaptations to reducing heat loss include:
Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
Other adaptations to reducing heat loss include:
Increased thermal insulation with fur, feathers, or fat
Ability to decrease blood flow to the skin by constricting blood vessels

34. Insects contract their flight muscles
Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
Some ectotherms are able to raise their body temperature by producing heat:
Insects contract their flight muscles
Honeybees regulate temperature as a group, adjusting individual heat and position in the cluster so that larvae are kept warm

35. Concept 29.4 Animals Control Body Temperature by Altering Rates of Heat Gain and Loss
Both endotherms and ectotherms may use behavioral regulation to maintain body temperature.
Examples: Lizard moving into sun or shade, or elephant spraying itself with water or dust

36. Thermostat in Mammals
In vertebrate brains, the hypothalamus is the major center of the thermostat.
The temperature of the hypothalamus can be the main feedback to the thermostat.
See Figure 30.7 A

37. Cooling the hypothalamus can cause body temperature to rise by:
Concept 29.5 A Thermostat in the Brain Regulates Mammalian Body Temperature
Cooling the hypothalamus can cause body temperature to rise by:
Constricting blood vessels to the skin
Increasing metabolic rate
Warming the hypothalamus can lower body temperature by:
Dilating blood vessels to the skin
Sweating or panting
See Figure 30.7 A

38. Figure 29.13 The Hypothalmus Regulates Body Temperature (Part 1)

39. Other factors can change hypothalamic set points:
Concept 29.5 A Thermostat in the Brain Regulates Mammalian Body Temperature
The temperature of the hypothalamus is a negative feedback signal—variability from its set point can trigger thermoregulatory responses.
Other factors can change hypothalamic set points:
Change in skin temperature
Wakefulness or sleep
Circadian rhythm—a daily internal cycle
ANIMATED TUTORIAL 29.1 The Hypothalamus

40. Fever is a an adaptive response to help fight pathogens.
Concept 29.5 A Thermostat in the Brain Regulates Mammalian Body Temperature
Fever is a an adaptive response to help fight pathogens.
The rise in body temperature is caused by a rise in the set point for metabolic heat production.
Some animals lower their temperature during inactive periods to conserve energy—daily torpor.
Long-lasting regulated hypothermia— hibernation