1. PRESS F1 FOR GUIDEANCE
PATHOLOGY
1st Practical
(Slides)
MFSH 2003

2. Inflammation & Repair Fibrinous pericarditis 5
Acute suppurative appendicitis 15
Foreign body reaction (pilonidal sinus) 22
Granulation tissue

3. General Key Information
Specific Point
Wide Area
Zooming
“higher magnification”
1,2,3,..etc
Numbers are used in identifying the needed histological layers.
Note:
Some cases have photos taken from more than one slide. They may differ a little bit.
Not all the features “written in the practical sheet” are shown in the slides, but only the ones important and the ones that I could see. (the best I can do)

4. Some cells you need to know
Inflammatory cells:
1)Lymphocyte
2)Neutrophil
3)Monocyte (macrophage)
4)Eosinophil
Fibrobast regenerates collagen.
When macrophages unite together the form multinucleated “Giant cells”.

5. Fibrinous pericarditis

6. 2- sub pericardial layer 3- myocardium
(1) Fibrinous pericarditis 1/9
1- pericardium
2- sub pericardial layer
3- myocardium 1 2 1 3 2

7. 1 2 1-Pinkish fibrinous exudate 2-Red cells 3-Inflammatory cells
(1) Fibrinous pericarditis 2/9 1
1-Pinkish fibrinous exudate
2-Red cells
3-Inflammatory cells 2
The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells.

8. 1 2 1-Pinkish fibrinous exudate 2-Red cells 3-Inflammatory cells
(1) Fibrinous pericarditis 3/9 1
1-Pinkish fibrinous exudate
2-Red cells
3-Inflammatory cells 2
The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells.

9. 1 2 1-Pinkish fibrinous exudate 2-Red cells 3-Inflammatory cells
(1) Fibrinous pericarditis 4/9 1
1-Pinkish fibrinous exudate
2-Red cells
3-Inflammatory cells 2
The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells.

10. 1 2 1-Pinkish fibrinous exudate 2-Red cells 3-Inflammatory cells
(1) Fibrinous pericarditis 5/9 1
1-Pinkish fibrinous exudate
2-Red cells
3-Inflammatory cells 2
The pericardium is distorted by thick irregular layer of pinkish fibrinous exudate with some red cells and inflammatory cells.

11. 1 2 3 4-Thickened by edema 5-Dilated blood vessels
(1) Fibrinous pericarditis 6/9
4-Thickened by edema
5-Dilated blood vessels
6-Chronic inflammatory cells 1 2 3
The sub pericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification

12. 1 2 3 4-Thickened by edema 5-Dilated blood vessels
(1) Fibrinous pericarditis 7/9
4-Thickened by edema
5-Dilated blood vessels
6-Chronic inflammatory cells 1 2 3
The sub pericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification

13. 1 2 3 4-Thickened by edema 5-Dilated blood vessels
(1) Fibrinous pericarditis 8/9
4-Thickened by edema
5-Dilated blood vessels
6-Chronic inflammatory cells 1 2 3
The sub pericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification

14. 1 2 3 4-Thickened by edema 5-Dilated blood vessels
(1) Fibrinous pericarditis 9/9
4-Thickened by edema
5-Dilated blood vessels
6-Chronic inflammatory cells 1 2
Every where 3
The sub pericardial layer is thickened by edema and shows dilated blood vessels, chronic inflammatory cells and areas of calcification

15. Acute suppurative
Appendicitis

16. 1- Lumen (normally empty) 2- mucosa A- epithelium 1
(2) Acute suppurative appendicitis 1/6 1 2 2 1 2B 2A
1- Lumen (normally empty)
2- mucosa
A- epithelium
B- lamina propria 1

17. 1-inflammatory exudates and pus cells
(2) Acute suppurative appendicitis 2/6
1-inflammatory exudates and pus cells
2-mucosa is ulcerated
Accumulation of inflammatory exudates and pus cells in the lumen and the mucosa is ulcerated

18. 1-inflammatory exudates and pus cells (lumen normally empty)
(2) Acute suppurative appendicitis 3/6
1-inflammatory exudates and pus cells (lumen normally empty)
2-mucosa is ulcerated
Accumulation of inflammatory exudates and pus cells in the lumen and the mucosa is ulcerated

19. 1-inflammatory exudates and pus cells in the lumen
(2) Acute suppurative appendicitis 4/6
1-inflammatory exudates and pus cells in the lumen
2-mucosa is ulcerated
(no epithelium present)
Accumulation of inflammatory exudates and pus cells in the lumen and the mucosa is ulcerated

20. 5-Exudate is present on the serosal surface
(2) Acute suppurative appendicitis 5/6
3-Congested blood vessels
4-Edema
5-Exudate is present on the serosal surface
All layers of the appendix wall show edema, dilated and congested blood vessels.
Fibrino-purulent exudate is present on the serosal surface.

21. 5-Exudate is present on the serosal surface
(2) Acute suppurative appendicitis 6/6
3-Congested blood vessels
4-Edema
5-Exudate is present on the serosal surface
All layers of the appendix wall show edema, dilated and congested blood vessels.
Fibrino-purulent exudate is present on the serosal surface.

22. Forign body reaction
(Pilonoidal sinus)

23. (3) Pilonidal sinus 1/7 1 A
Sinus Tract 2 A B 1 2 B 1 2
Note: The sinus tract, doesn’t always appear on section. Depending on the cut of the section. (see above)

24. Sinus tract 1-inflammatory granulation tissue in dermis
(3) Pilonidal sinus 2/7
1-inflammatory granulation tissue in dermis
Sinus tract
A sinus tract lined by inflammatory granulation tissue in dermis

25. Sinus tract 1-inflammatory granulation tissue in dermis
(3) Pilonidal sinus 3/7
1-inflammatory granulation tissue in dermis
(see granulation tissue in the next slide)
Sinus tract
A sinus tract lined by inflammatory granulation tissue in dermis

26. 4-lymphocytes, macrophage & neutrophils
(3) Pilonidal sinus 4/7
2-hair shafts
3-giant cells
4-lymphocytes, macrophage & neutrophils
The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes, macrophage & neutrophils.

27. 4-lymphocytes, macrophage & neutrophils
(3) Pilonidal sinus 5/7
2-hair shafts
3-giant cells
4-lymphocytes, macrophage & neutrophils
The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes, macrophage & neutrophils.

28. 4-lymphocytes, macrophage & neutrophils
(3) Pilonidal sinus 6/7
2-hair shafts
3-giant cells
4-lymphocytes, macrophage & neutrophils
The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes, macrophage & neutrophils.

29. 4-lymphocytes, macrophage & neutrophils
(3) Pilonidal sinus 7/7
2-hair shafts
3-giant cells
4-lymphocytes, macrophage & neutrophils
The lumen of sinus and wall contain large number of hair shafts with foreign body giant cells, lymphocytes, macrophage & neutrophils.

30. Granulation
tissue

31. 1-Small newly formed capillaries
(4) Granulation tissue 1/9
1-Small newly formed capillaries
Many small newly formed capillaries lined by plump endothelial cells.

32. 1-Small newly formed capillaries
(4) Granulation tissue 2/9
1-Small newly formed capillaries
(every where)
Many small newly formed capillaries lined by plump endothelial cells.

33. 2-Fibroblast Proliferation of fibroblast is seen
(4) Granulation tissue 3/9
2-Fibroblast
Proliferation of fibroblast is seen

34. 2-Fibroblast Proliferation of fibroblast is seen
(4) Granulation tissue 4/9
2-Fibroblast
Proliferation of fibroblast is seen

35. (4) Granulation tissue 5/9
3-Inflammatory cells
Inflammatory cells including macrophages, lymphocytes, plasma cells and neutrophils in the oedematous stroma.

36. Plasma cell (not quite sure)
(4) Granulation tissue 6/9
3-Inflammatory cells
Neutrophils
Plasma cell (not quite sure)
Lymphocyte (not quite sure)
Inflammatory cells including macrophages, lymphocytes, plasma cells and neutrophils in the oedematous stroma.

37. 4-collagen fibers Pink homogenous collagen fibers may be identified
(4) Granulation tissue 7/9
4-collagen fibers
Pink homogenous collagen fibers may be identified

38. 4-collagen fibers (pink areas)
(4) Granulation tissue 8/9
4-collagen fibers
(pink areas)
Pink homogenous collagen fibers may be identified

39. 4-collagen fibers (pink areas)
(4) Granulation tissue 9/9
4-collagen fibers
(pink areas)
Pink homogenous collagen fibers may be identified

40. الله لا إلَه إلا هُو الحَيُّ القَيّومُ
دعواتكم يا شباب

41. I hope it was useful.
A word can change the outcome of many things. So, if you either liked or didn’t like this project, why keep your thoughts to yourself ?
Send us your comments and ideas to It will mean too much to us, “even if it was just one word”
THANX
MFSH 2003