1. New Drug Capacity Calculator Instruction Manual An Excel-based tool for estimating the resource required to deliver newly approved chemotherapy drugs. This tool was developed by GSK on behalf of the Pharmaceutical Industry Partnership Group (PIPG) ZINC Code : UK/ONC/0013/13d Date of Preparation: 11/06/2014

2. Click on the “Enter the model” button or use the tab at the bottom of the worksheet to go to the “Introduction” sheet. Sheet 1 - Cover

3. This worksheet has been designed to introduce the user to the New Drug Capacity Calculator and allows the user to navigate directly to specific sheets in the tool using the blue buttons. Sheet 2 - Introduction

4. No data input is required on this sheet. Sheet 2 - Introduction Functionality Use arrows or blue navigation buttons to move to next page. Please read the disclaimer.

5. Sheet 3 – Chemotherapy Pathway This sheet has been designed to introduce the user to the Chemotherapy Pathway, as described in the NHS Standard specification template for adult systemic anti-cancer therapy services (April 2013). Although the pathway may vary slightly according to local practice, the general flow of the patient through this pathway should be similar in different parts of the country.

6. Click home button to return to the Introduction sheet. Reference for document that describes the pathway. Describes the service area where capacity calculation will be shown in the summary. Sheet 3 – Chemotherapy PathwayFunctionality Green boxes represent areas of the pathway where capacity is being calculated.

7. Sheet 4 – Treatment Plan (1) This sheet allows the user to put together a treatment plan for a cohort of patients. The delivery time for delivering a new drug regimen to a cohort of patients is calculated on the basis of the input data.

8. Sheet 4 – Treatment Plan (2) Input the number of treatment cycles and the number of patients in this section of the treatment plan worksheet.

9. Sheet 4 – Treatment Plan Select “None” in “Drug type” “Route” or “infusion type” to blank out rows. Use drop-down buttons to input details of the regimen. Input data manually in the white boxes that do not contain drop-down lists. Functionality The headers for tables 1a and 1b contain information in the comments boxes. Sum of infusion and observation times for specified number of cycles for the whole cohort of patients. Follow the instructions in Steps 1, 2 and 3. Throughout the tool some cells contain additional information in the comments box (as denoted by a red triangle). Hover your mouse over the red triangle in the corner of the cell to view the information.

10. Sheet 5 – Pharmacy Capacity This sheet allows the user to calculate the pharmacy capacity needed to deliver the newly approved medications. It calculates the time needed for items that require aseptic preparation and those that are pre-filled items. The output is expressed in Whole Time Equivalents (WTE) days for pharmacy staff and the isolator time needed to deliver the regimen to a cohort of patients.

11. Sheet 5 – Pharmacy Capacity Use the drop-down buttons to input data on the variable time activities. Functionality Data on the number of patients, cycles and items is drawn from the “Treatment plan” sheet. Select hyperlink to “Pharmacy References” sheet to change or review fixed times. Select hyperlink to “local Assumptions” page to whole time equivalent (WTE) figure which is set at a default figure of 5.4 hours. Input data manually in the white box for isolator cleaning time multiplier.

12. Sheet 6 – Nurse Capacity This sheet allows the user to calculate the nurse capacity needed to deliver the newly approved regimen. It calculates the time needed for the nurses to deliver the specified regimen for a cohort of patients. The output is expressed in WTE days of nurse staff resource needed for delivery of the regimen.

13. Input the total time per patient for the activities described in steps 2, 3 and 5. Cycle 1 data may be entered separately from that of subsequent cycles. Nurse activities that require chair time and those that do not, need to be entered in different sections of the table. Use the drop-down buttons to input data. Nurse resource that requires chair time and total nurse resource is calculated. Sheet 6 – Nurse CapacityFunctionality

14. Sheet 7 – Chair Capacity This sheet shows the chair capacity needed to deliver the newly approved regimen for a cohort of patients.

15. Sheet 7 – Chair Capacity Shows the different drug types that need to be delivered for the new regimen in the chemotherapy unit. Data is drawn from the “Treatment plan” and “Nurse Capacity” sheets. The default setting is that each chair is bookable for 7.5 hours/day Functionality No data input is required on this sheet.

16. Sheet 8 – Pathway Results This sheet collates the capacity information on resources needed to deliver the newly approved regimen. It is designed to act as a snap-shot of the collated resources and may be used to provide an overview of the overall capacity needed for delivery of a newly approved drug regimen. As it draws on the inputs from previous sections, the previous worksheets have to be completed before the overview can be generated.

17. Sheet 8 – Pathway Results Grey boxes indicate which capacities have been calculated. Functionality The totals on the Pharmacy, Nurse and Chair Capacity worksheets are summarised here.

18. Sheet 9 –Results Table The results are tabulated on this worksheet. No inputs are required.

19. This sheet shows the information on the local assumptions that are used in the Capacity Calculator tool. The assumptions currently used are derived from the data that has been provided by the Newcastle Cancer Centre. Sheet 10 – Local Assumptions To change the WTE, input the number of hours/day manually into the white box. Time available for performing fixed time tasks. For details of the actual times used in the fixed time calculations, refer to the “Pharmacy References” page. Functionality To change the number of hours that the chemotherapy unit is open, input the number of hours manually into the white box.

20. This sheet gives details of the aseptic preparation fixed times used in the pharmacy capacity calculations. The times that are currently in the tool are derived from the data that has been provided by the Newcastle Cancer Centre. If local data needs to be used, the data in the white boxes can be changed manually. Sheet 11 – Pharmacy references

21. Sheet 12 – Activity Tariffs This sheet shows the likely tariff costs for delivery of the new chemotherapy regimen.

22. Sheet 12 – Activity TariffsFunctionality Use hyperlink to review national tariff Information. Select “Yes” in Step 1 if the new regimen is comprised totally of oral drugs. Use this section of the worksheet for activities that are not on the national tariff list. Manually input the tariff in the white box. For parenteral drugs select “Yes” once in this section.

23. Sheet 13 Tariff Information Details of the HRG codes and tariff costs used in the calculation of the activity tariffs are given on this sheet. The reference is also provided.