1. Overview of the Chemical Threat Laboratory of Texas William Edgemond, Ph.D. Texas Department of State Health Services October 2013

2. Course Objectives  Introduction and Background  Who We Are  What We Can Do  What We Want You to Do

3. Chemical Threats

4. Laboratory Response Network International network of laboratories to respond quickly to high priority public health emergencies, such as biological, chemical, and radiological threats, through training, rapid testing, timely notification and secure messaging of laboratory results.

5. LRN-C Structure CDC Level 1 10 Labs Level 2 & Level 3 Activities National Surge Capacity Core Methods & Add’l Methods Additional Personal & Instruments Level 2 34 Labs Level 3 Activities Core Methods State/Local Response Capacity Level 3 9 Labs Competency in collecting and shipping clinical samples Comprehensive response plan

7. US Chemical Threat Labs           Level 1 Level 3 Level 2

8. Course Objectives  Introduction and Background  Who We Are  What We Can Do  What We Want You to Do

9. Personnel  Dr. Bill Edgemond Team Lead/Chemical Threat Coordinator  Jim Barnes Chemist  Jocelyn Hover-Jeansonne Chemist

10. How We Will Respond  Can easily handle a large number of samples utilizing Lab Check-in personnel and space

11. Types of Samples  Clinical Samples Blood Urine  Environmental/White Powders

12. Clincal Methods  CAP/CLIA Accredited Lab  11 Methods Developed by CDC 3 GC/MS Methods 4 LC-MS/MS Methods 3 ICP-MS Methods 1 LC-ICP-MS Methods

13. Instrumentation & Capabilities  Biosafety L2 Hood  Chemical Hoods  Automated Liquid Handler  Bar Code Reader  LIMS

14. GC-MS  Cyanide in Blood  Volatile Organic Compounds in Blood  Tetramine in Urine

15. ICP-MS  Cadmium, Lead, & Mercury in Blood  Trace Elements in Urine (Be, Co, Mo, Cd, Sb, Cs, Ba, W, Pt, Tl, Pb, U)  Arsenic & Selenium  LC-MS-ICP Lewisite (Chlorovinyl arsonous acid)

16. LC-MS/MS  Abrine/Ricinine  Organophosphorous Nerve Agent Metabolites  Tetranitromethane Metabolite (HNPAA)  Monofluoroacetate/ Monchloroacetate

17. Unknowns/White Powders  Typical submitted by FBI  Cleared by Bio Threat  Classify type of compound

18. Texas CT Lab  Know we’re here.  Know what we can do.  Share that with labs, hospitals and first responders across the state.

19. Unknowns/White Powders  FT-IR  FT-IR Microscope  XRF  Geiger Counter  Volatiles Detector  Wet Chemistry Tools

20. CT Lab Contact Info  512-458-7270—Direct Lab Phone.  512-689-9945—24-hour Emergency Phone.  William.edgemond@dshs.state.tx.us – Chemical Threat Coordinator William.edgemond@dshs.state.tx.us  http://www.dshs.state.tx.us/lab/epr.shtm -- DSHS Chemical Emergency Website http://www.dshs.state.tx.us/lab/epr.shtm  http://emergency.cdc.gov/chemical/lab.asp -- CDC Chemical Emergency Website http://emergency.cdc.gov/chemical/lab.asp

21. Texas CT Lab

22. Questions