1. Genetics I. Introduction A. A. History

2. 1. C. C. Darwin & A. A. Wallace  blending 2. G. G. Mendel & F. F. Unger  mixing 3. W. Sutton  Chromosomal theory of Inheritance 4. T. Morgan  Genes & Chromosomes plus linkage groups

3. 5. A. A. Sturtevant  genetic mapping 6. F. F. Griffith  hereditary molecule 7. O. Avery etal.  DNA hereditary molecule 8. B. McKlintock  Transposons

4. 9. W. W. Fiers  sequenced viral gene 10. A. A. Jeffreys  DNA finger printing 11. 1995  Viral DNA sequenced 12. 1996  yeast DNA sequenced 13. 1998  round worm DNA sequenced 14. 2003  human DNA sequenced

5. II. Mendelian 1. 1. Monohybrid Cross A. A. Experimental Design

6. a. Definition b. Terms i. Self vs. Cross Fertilization ii. Traits vs. Characteristics

7. c. Process

8. c. Process Figure 14.2

9. c. Process Figure 14.3

10. Figure 14.4 d. Principle  traits are paired and sorted

11. d. Principle  traits are paired and sorted Figure 14.5

12. i. Gene versus Allele ii. Homozygous versus Heterozygous iii. Dominance versus Recessive iv. Genotype versus Phenotype e. Terms

13. Figure 14.6

14. f. Testcross Figure 14.7

15. f. Testcross

16. 2. 2. Dihybrid Cross

17. a. Definition b. Process Start by figuring out how many and type of gametes Figure 14.8

18. Dihybrid Heterozygous cross = Phenotypic ratio= 9:3:3:1, Genotypic ratio= 1:1:2:2:4:2:2:1:1 Dihybrid Heterozygous cross Homozygous Dominant = Phenotypic ratio = all dominant, Genotypic ratio = 1:1:1:1 c. Principle  Each pair of alleles and chromosomes sort independently into gametes. AaBb X AABB Gametes AaBb = AB, Ab, aB, & ab; AABB= AB only Practice AaBb X AaBb Gametes AaBb = AB, Ab, aB, & ab for both

19. III. Variation on Mendel A. A. Dominance

20. AA aa Aa 2. Co-dominance 1. Complete

21. 3. Incomplete dominance Figure 14.10

22. B. B. Gene Interactions

23. 1. Multiple Alleles

24. 2. Pleitrophy3. Penetrance

25. C. C. Beyond Mendel

26. 1. Epistasis

27. 2. Polygenic Figure 14.11

28. 2. Polygenic Figure 14.12

29. IV. Classical Genetics A. A. History

30. Figure 14.9 1. R. R. Punnet & W. W. Bateson  ???

31. a. Drosophila melangastor Figure 15.3 WHY? 2. T. Morgan  Genes & Chromosomes, Karyotyping, plus linkage groups

32. Figure 15.4

33. b. Genetic Recombination

34. Figure 15.5

35. b. Genetic Recombination

36. 3. A. Sturtevant  Genetic Mapping Based on frequency of expression of traits showing together Figure 15.6

37. Based on frequency of expression of traits showing together 3. A. Sturtevant  Genetic Mapping Figure 15.7

38. Based on frequency of expression of traits showing together 3. A. Sturtevant  Genetic Mapping Figure 15.8

39. B. B. Sex Linkage

40. 1. Basis of SEX

41. 1. Basis of SEX Figure 15.9

42. 1. SEX linked inheritance Figure 15.9

43. a. Barr Bodies Figure 15.11

45. V. Detection of Problems A. A. Techniques

46. 1. Karyotyping 2. Amniocentesis == Cellular and Chemical Analysis Figure 14.17

47. 3. Ultrasound 4. Chorionic Villi Sampling == Cellular and Chemical Analysis Figure 14.17

48. 5. Fetal Tissue Sampling

49. 6. Pedigree Analysis Figure 14.14

50. 6. Pedigree Analysis

51. 6. Pedigree Analysis

52. Learning can be such sweet sorrow.