1. DZAB Medical Incorporated Della Hasan Amber McCreary Bianca Bullock Zain Bhatti

2. The Kidney

3. Why do our Kidney’s Fail? Kidney failure develops when the kidney becomes less effective at filtering out waste products, water and salt from the blood

4. Figure 1: The Association Between Creatinine and Kidney Function ( This figure plots the amount of kidney function as calculated by the Cockcroft-Gault formula for a 55-year-old white male.)

5. Statistics and cost 26 million American adults have CKD and millions of others are at increased risk $44,000 per year per patient spent on Dialysis In 2007, Medicare spent $8.6 billion on the treatment and medication of dialysis patients Medical cost of kidney transplant averages around $262,900

6. Mission Statement We at DZAB are advocates for life. Many doubts surround stem cell research, however in reality it may be one of the most effective and natural way of curing,many diseases today. What better way to heal the body than with natural cells that one is ultimately made up of. At DZAB Medical Inc. we are taking medicine and innovation to the next step in developing the first functional adult size kidney from stem cells.

7. Stem Cell Research

8. Types of stem cells (All stem cells regardless of their source have three general properties: they are capable of dividing and renewing themselves for long periods; they are unspecialized; and they can give rise to specialized cell types.) Embryonic stem cells Somatic “Adult” stem cells

9. Why must we develop an Adult size kidney? “British scientists have created human kidneys from stem cells …..They are currently half a centimetre in length - the same size as kidneys found in an unborn baby”-The Telegraph

10. Properties of our Kidney Courtesy of Dr. Narayan Bhattarai, Ph.D. (Assistant Professor Chemical, Biological and Bioengineering )

11. The transplant Biocompatibility Medical advances Before

12. Post-surgery treatment and maintenance Post-surgical treatment would be the same as any other surgery involving a transplant:  Post-surgery treatment after heart bypass  Sixteen of the patients were infused with stem cells  Fourteen patients showed the heart pumped efficiency from 30%-40% after 100 days  To maintain any transplant one must  Reduce or avoid stress  Avoid sugar rich food  Avoid tobacco and alcohol In order to keep the body healthy, and prevent any further complications

13. Natural kidney’s vs. stem celled kidney Developing a kidney from stem cells allows it to has the same functions as any kidney that a healthy person possess.  Nephron  Renal vein  Renal artery  Renal medulla  Renal vein  Interlobular artery and vein  Nephron Tubules  Ureter  Renal cortex  Renal pelvis  Arcuate artery and vein

14. Work cited  http://EzineArticles.com/1342892 http://EzineArticles.com/1342892  http://www.dailymail.co.uk/health/article-1376044/Human- kidneys-created-stem-cells-organ- breakthrough.html#ixzz1snhqRnTn http://www.dailymail.co.uk/health/article-1376044/Human- kidneys-created-stem-cells-organ- breakthrough.html#ixzz1snhqRnTn  http://www.kidney.org/kidneydisease/aboutckd.cfm#facts  http://www.transplantliving.org/before-the- transplant/financing-a-transplant/the-costs/ http://www.transplantliving.org/before-the- transplant/financing-a-transplant/the-costs/  http://kidney.niddk.nih.gov/KUDiseases/pubs/kustats/index.asp xhttp://kidney.niddk.nih.gov/KUDiseases/pubs/kustats/index.asp x  http://www.sciencedirect.com/science/article/pii/S136970210 4002330  http://www.nanowerk.com/spotlight/spotid=8030.php http://www.nanowerk.com/spotlight/spotid=8030.php  http://healthland.time.com/2011/11/14/first-human-heart- stem-cell-trial-shows-promise/#ixzz1tCUk4k00 http://healthland.time.com/2011/11/14/first-human-heart- stem-cell-trial-shows-promise/#ixzz1tCUk4k00  http://www.stemcellmd.org/guidelines-for-a-stem-cell-patient/ http://www.stemcellmd.org/guidelines-for-a-stem-cell-patient/