1. INFECTIVE ENDOCARDITIS and valvular vegetations Alex Yartsev 30/03/2010

2. Pathological definitions INFECTIVE ENDOCARDITIS The colonization or invasion of heart valves or the mural endocardium by a microbe VEGETATIONS Masses of thrombotic debris and organisms, attached to valves or myocardial tissue, and destructive to that tissue Robbins and Cotran Pathologic Basis Of Disease (8 th ed)

3. A vegetation Robbins and Cotran Pathologic Basis Of Disease (8 th ed) Subacute Mitral Endocarditis, Strep viridans Acute endocarditis of congenitally bicuspid aortic valve, by Staph aureus

4. Acute IE or Subacute IE? Definition dependent on virulence and course ACUTE: 10-20% of cases Infection of a normal valve Rapidly progressing, usually Staph Aureus Rapidly destructive, necrotising, ulcerative SUBACUTE – 80-90% of cases Infection of a previously diseased, deformed valve Slowly progressing, usually Streptococcus Gradually destructive, more like erosive Robbins and Cotran Pathologic Basis Of Disease (8 th ed)

5. There are 3 main pathogens Defective valves: – 60% of cases its Streptococcus viridans Normal valves – Staph Aureus especially if the valve belongs to an IV drug user Prosthetic valves: -Staph epidermitis OTHER ORGANISMS:Enterococci, Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella… All oral organisms In 10-15% of cases, no organism is found. Robbins and Cotran Pathologic Basis Of Disease (8 th ed)

6. A Word About Streptococci Alpha hemolytic: reduce iron from hemoglobin – Strep pneumoniae, Strep viridans Beta hemolytic: lysis of whole RBCs – Group A: S.pyogenes  rheumatic fever – Group B: S.agalactiae  neonatal meningitis – Group C: S.equi  “distemper of horses” – Group D: Enterococci – Group G: S.canis  dog saliva

7. FOREMOST: Anything that predisposes to bacteraemia Dental procedures, oral infections,IV drug use, surgery, IV cannulas, central lines, huge obvious infections elsewhere, or minute trivial areas of slightly broken skin Predisposing factors

8. Rheumatic heart disease Mitral valve prolapse Degenerative calcific valvular stenosis NORMAL bicuspid aortic valve Prosthetic valves Unrepaired and repaired congenital defects Robbins and Cotran Pathologic Basis Of Disease (8 th ed)

9. Complications Brain abscess Lung abscess Heart failure Glomerulonephritis (immune complexes) Emboli  anywhere

10. Common clinical Features Fever, chills, rigors New heart murmr New onset of heart failure signs/symptoms Problems otherwise unexplained: Brain abscesses Lung abscesses Glomerulonephritis

11. Uncommon clinical features Roth spots (Retinal hemorrhages) Janeway lesions (painless microabscesses ) Oslers nodes (painful immune complex deposits) Robbins and Cotran Pathologic Basis Of Disease (8 th ed) Tally and O’Connor

12. Populations at risk IV drug users: usually tricuspid valve Valve replacement patients Patients with repaired or unmanaged septal defects Past history of rheumatic heart disease

13. Preventative measures COCHRANE: “There remains no evidence about whether penicillin prophylaxis is effective or ineffective against bacterial endocarditis in people at risk who are about to undergo an invasive dental procedure. “

14. Diagnosis Duke criteria: MAJOR citeria – Streptocucus viridans in blood culture – Staph aureus in blood culture in absence of primary focus – Persistently positive blood culture: organism consistent with infective endocarditis from Blood cultures drawn more than 12 hours apart, or all of three, or majority of four or more separate blood cultures, with the first and last drawnat least 1 hour apart – Evidence of Endocardial involvement: +ve ECHO

15. Diagnosis: Duke Criteria MAJOR CITERIA – Positive blood culture, for a characteristic organism – Echo identification of a valvular mass or partial separation of an artificial valve Need 2 major Or 1 major and 3 minor Or 5 minor criteria

16. Diagnosis: Duke Criteria MINOR CITERIA – Predisposing heart lesion – IV drug use – Vascular lesions eg. splintr hemorrhages or petechiae – Immunological phenomena eg. Oslers nodes, Roth spots – Single culture positive for an unusual organism – Echo findings consistent with but not diagnostic of endocarditis

17. TTE or TOE? TTE for aortic valve TOE for mitral, pulmonary, tricuspid TTE less sensitive for vegetations than TOE

18. Practical Management Delay of diagnosis = lower survival Three sets of cultures before antibiotics; Then, commence empiric therapy Continue for 6 weeks Ohs Intensive Care Manual 6 th ed; Therapeutic Guidelines

19. Empirical antibiotics Therapeutic Guidelines suggest: – Benzylpenicillin 1.8 g q4h, PLUS – Flucloxacillin 2g q4h PLUS – Gentamicin 6mg/kg daily ALSO – Add Vancomycin if the pt has a prosthetic valve or the infection is hosptial-acquired

20. Good Evidence COCHRANE: “There remains no evidence about whether penicillin prophylaxis is effective or ineffective against bacterial endocarditis in people at risk who are about to undergo an invasive dental procedure. “ Most people still use ampicillin or clindamycin Antibiotics for the prophylaxis of bacterial endocarditis in dentistry: Oliver et al, 2008