1. Helping Promote Vaccination HPV-Related Cancers Problem Space Sabita Saldanha, Alabama State University Tamara McEwen, Southwestern College BioQUEST 2013 Summer Workshop Emory University 15 June 2013

2. Introduction to HPV Problem Set Target Audience: Introductory Undergraduate Courses Biology, Microbiology, Immunology, Public Health Objectives: To increase data literacy through graphical analysis To examine the impact of socioeconomic status and the economic factors on HPV incidence and mortality rates To increase ethical reasoning skills regarding the possibility of mandatory vaccinations Biological Principles: Certain viruses cause cancer. HPV causes many cancers including cervical, anal, penile, vaginal, and oropharyngeal. HPV-16 and HPV-18 are responsible for an overwhelming majority of these cancers. https://www.youtube.com/watch?feature=player_embedded&v=ClD1gnX nl-E https://www.youtube.com/watch?feature=player_embedded&v=ClD1gnX nl-E Vaccination can prevent most virally-induced cancers.

3. Analysis Tools and Activities Graphical Analysis Excel Gapminder Google Charts Sequence Analysis CaseIT with BLAST or tree 1.Interpret Figure A (Lowy & Schilling), includes written description and class discussion Cancer Prev Res 2012 Jan 5(1) 18-23, Figure 1.pptCancer Prev Res 2012 Jan 5(1) 18-23, Figure 1.ppt 2.Compare and contrast incidence and mortality rates of cervical cancer (developed vs developing) by graphing. Tables 4 and 5 WHO.pptxTables 4 and 5 WHO.pptx 3.Analyze future projections of incidence and mortality rates by graphing. Figures 10 and 16 WHO.pptxFigures 10 and 16 WHO.pptx 4.Write opinion summary accepting or rejecting data in favor of vaccination, which includes opinion regarding mandatory vaccination. 5.Compare and contrast various sero-types of HPV based on sequence alignment.

4. Bibliography CaseIT Project© University of Wisconsin-River Falls. 2012. Date Accessed 14 Jun 2013. Available at www.caseitproject.org. www.caseitproject.org Human Papillomavirus (HPV): What is HPV? Centers for Disease Control and Prevention, USA.gov. 5 Feb 2013. Date Accessed 13 Jun 2013. Available at www.cdc.gov/hpv/whatishpv.html. www.cdc.gov/hpv/whatishpv.html Human Papillomavirus (HPV): HPV Vaccines. What is Centers for Disease Control and Prevention, USA.gov. 5 Feb 2013. Date Accessed 13 Jun 2013. Available at www.cdc.gov/hpv/vaccine.html. www.cdc.gov/hpv/vaccine.html Jaslow, Ryan. Oral Sex and Throat Cancer: Michael Douglas HPV report spotlights “epidemic”. 5 Feb 2013. 3 Jun 2013. Date Accessed 13 Jun 2013. Available at www.cbsnews.com/8301-204_162- 57587350/oral-sex-and-throat-cancer-michael-douglas-hpv-report-spotlights-epidemic. www.cbsnews.com/8301-204_162- 57587350/oral-sex-and-throat-cancer-michael-douglas-hpv-report-spotlights-epidemic Lowy, Douglas R. and Schiller, John T. Reducing HPV-Associated Cancer Globally. Cancer Prev Res 2012 5:18-23. Molina, Gaby. Infeccion por PVH. 13 Mar 2010. Date Accessed 13 Jun 2013. Available at www.youtube.com/watch?feature=player_embedded&v=ClD1gnXnl-E. www.youtube.com/watch?feature=player_embedded&v=ClD1gnXnl-E Tamura K, Peterson D, Peterson N, Stecher G, Nei M, and Kumar S (2011) MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Molecular Biology and Evolution 28: 2731-2739. MEGA, Software accessed 14 Jun 2013. Available at http://megasoftware.net.Molecular Biology and Evolutionhttp://megasoftware.net Viruses and Cancer. CancerQuest. Winship Cancer Institute, Emory University. 2013. Date Accessed 13June2013. Available at www.cancerquest.org/viruses-cancer.html.www.cancerquest.org/viruses-cancer.html WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in World Summary Report 2009. Date Accessed 10Jun2013. Available at www.who.int/hpvcentre.www.who.int/hpvcentre