1. 4 Joseph Lepselter, Director Clinical Department March 1, 2012 DRAFT CONCEPT

2. כל הזכויות שמורות © Face Rejuvenation 4

3. Photos Courtesy: Fernando Stengel, M.D., Dermatologist, Buenos Aires, Argentina Décolleté Rejuvenation 4

4. כל הזכויות שמורות © Hand Rejuvenation 4

5. Program The aim of the new program is to treat the major photodamaged photoaged face, décolleté and hand-related imperfections - pigmentation, laxity, rhytides and volume, using 4 Harmony XL advanced light and laser technology. 4

6. Objective The objective of the 460 rejuvenating program is to remove photodamaged photoaged skin pigmentations and superficial blood vessels, tighten the laxed aged skin, décolleté and the dorsal aspect of the hand

7. Background (I) Face, décolleté and hands are one of the first parts of the body to show signs of aging because they receive so much exposure. Sunlight, the elements and the natural aging process all contribute to the development of darkened spots, precancerous growths and a loss of fatty tissue.

8. Background (II) Veins become much more prominent with deepening color enhancement. The anatomy of the tendon becomes more accentuated. Skin wrinkles become much more prevalent with the loss of fullness and elasticity in the deep dermal layer. Intermetacarpal wasting becomes more enhanced with volume loss.

9. Photdamage The most typical cause of darkened areas of skin, brown spots or areas of discoloration is unprotected sun exposure. Once incorrectly referred to as liver spots, these pigment problems are not connected with the liver.

10. The Aging Face, Décolleté, Hand Level I – Epidermis –Pigmentation –Vascular lesions Level II – Dermis –Rhytides –Laxity Level III – Hypodermis –Laxity

11. 460 Rejuvenation Pigmented/Vascular Lesions Laxity Texture, Tone Rhytides

12. Rejuvenation Modules Dye-SVL QSW Pixel IMPACT iPixel Er:YAG

13. QSW Dye-PL NIR

14. Modules Dye-PL NIR Nd:YAG QSW Pixel Er:YAG iPixel Light 500-600-nm Light 800-1600-nm Laser 1064-nm Laser 2940-nm

15. Modules Intended Use Dye-PL NIR Nd:YAG QSW Pixel Er:YAG iPixel Vascular/pigmentati on shading Topical Heating Non-ablative skin remodeling Fractional ablative skin remodeling

16. Dye-PL Indications Vascular & Pigmented Lesions –port wine stains –facial telangiectasia –Rosacea –Solar lentigenis

17. iPixel Er:YAG Indications Fractional skin resurfacing Fine-lines and wrinkles Skin laxity Scars including acne scars Stretch marks Photodamaged and photoaged skin

18. QSW Pixel Indications Fractional skin resurfacing Fine-lines and wrinkles Skin laxity Scars including acne scars Stretch marks Photodamaged and photoaged skin

19. QSW Pixel Secondary Indications Crows feet Frontal lines Melasma Deeper dark scars Deeper pigmentation Dark eye circle Unwanted dermal filler / lumps from dermal filler Rosacea Telangiectasia

20. NIR Indications Skin tightening

21. Protocol Day 1 Color + Tightening Dye-PL, NIR Day 20 Color +Tightening QSW, NIR Day 30 Rhytides iPixel Er:YAG Day 50 Color +Tightening Dye-PL, NIR Day 60 Rhytides iPixel Er:YAG 4

22. BeforeAfter 4 th txt

23. Before 3 weeks After 1 Tx

24. Before 3 weeks After 1 Tx

25. Before R 3 weeks After 1 Tx

26. Before 3 weeks After 1 Tx L