1. Deep Brain Stimulation Therapy for Parkinson’s Disease Perry C. Benefiting from DBS Therapy since 2007

2. Motor Fluctuations and Dyskinesias Decrease Quality of Life for People with Parkinson’s Disease 1 In the United States more than 1 million people living with Parkinson’s disease (PD) 2 Levodopa generally provides smooth and stable benefits for up to 5 years 3 After this period, patients may experience increasingly troublesome and unpredictable motor fluctuations and dyskinesias 3 1.Adler, CH. Relevance of motor complications in Parkinson’s disease. Neurology. 2002;58(Suppl 1):S51-S56. 2.National Parkinson’s Foundation (www.parkinson.org/Page.aspx?pid=225) accessed site, Dec. 3, 2009. 3.Melamed E, Ziv I, Djaldetti R. Management of Motor Control Complications in Advanced Parkinson's Disease. Movement Disorders, 2007;22(Suppl. 17)S379-S384.

3. Treating motor fluctuations and dyskinesias requires moving beyond standard dopamine replacement therapy 3 The delayed “on,” wearing off, and dose failure of levodopa may be due to its impaired absorption, short half-life, and the loss of striatal dopamine storage capacity 3 When drugs become less reliable, Medtronic DBS Therapy (Deep Brain Stimulation) should be considered to achieve PD treatment goals According to the American Academy of Neurology (AAN), “10% to 20% of people with PD may be eligible for surgical treatments” 4 3. Melamed E, Ziv I, Djaldetti R. Management of Motor Control Complications in Advanced Parkinson’s Disease. Movement Disorders. 2007;22(Suppl. 17)S379-S384. 4. AAN Guidelines for patients and their families: medical and surgical treatment for motor fluctuations and dyskenisias in Parkinson’s disease. April, 2006.

4. How Does Medtronic DBS Therapy Work? One or 2 leads are implanted to deliver electrical stimulation to parts of the brain involved in movement control, including the globus pallidus (GPi) or subthalamic nucleus (STN) Current delivered by the lead is believed to disrupt and modulate abnormal motor circuit activity in the brain caused by PD, thereby smoothing out motor function The exact mechanism of action isn’t completely understood

5. Medtronic DBS Therapy with Medications Provides an Additional 5.1 Hours of “On” Time to Smooth Out Motor Function Throughout the Day 5 * This chart is for illustrative purposes and does not reflect actual “on” or “off” time. Without DBS Therapy With DBS Therapy 5. Activa Therapy Clinical Summary, 2009.

6. Medications were reduced 25% on average for patients receiving DBS Therapy 5 Results from prospective multicenter randomized control trial of patients with advanced PD 5 5. Activa Therapy Clinical Summary, 2009. Additional “On” Time Without Dyskinesias 5 0 1 2 3 4 56 5.1 hours 0 hours DBS Therapy + BMT (n=108) BMT Alone (n = 118) Mean Additional Hours of “On” Time Without Dyskinesias P<0.001 *Results were at 6 months post implant versus baseline. 4 5.1 Hours of Additional “On” time Without Dyskinesias Compared to Best Medical Therapy (BMT) 5 Best Medical Therapy Defined Patients who received BMT were managed actively by movement disorder neurologists. Patients received state-of-the-art care, including the active management of medications and non-pharmacological therapy (e.g., physical occupational, and speech therapy) as needed to achieve best symptom control.

7. In a Separate Study, DBS Therapy Was Shown to Maintain Symptom Improvements After 5 Years 6 1 Year (n = 43) 3 Years (n = 42) 5 Years (n = 42) Percent Improvement in “Off” Medication UPDRS Motor Scores Compared with Pre-DBS Therapy Baseline 6 100 80 60 40 20 0 Rigidity TremorAkinesia p < 0.001 5 years after surgery versus baseline 73% 75% 63% 74% 83% 52% 71% 75% 49% 6. Krack R, Batir A, Van Blercom N, et al. Five-Year Follow-up of Bilateral Stimulation of the Subthalamic Nucleus in Advanced Parkinson’s Disease. N Engl J Med. 2003;349:1925-34.

8. Proven Safety Profile Improvements in MRI imaging, stereotactic equipment and software, and patient selection have all helped advance DBS Therapy since the FDA first approved it in 1997 Although there was a significantly higher incidence of serious adverse events observed in patients receiving DBS Therapy, 99% of serious adverse events were resolved by 6 months 5 The majority of serious adverse events* with DBS Therapy are procedure related and temporary 5 * A serious adverse event was defined according to FDA regulations as any event that: results in death, is life-threatening, results in prolonged or new hospitalization, results in disability or congenital anomaly/birth defect, or requires medical or surgical intervention to prevent one of the above outcomes. 5. Activa Therapy Clinical Summary, 2009.

9. What are the Risks Associated with DBS Therapy? There are risks to consider with DBS Therapy, as is the case with any brain surgery. Be sure to discuss the possible surgical complications and side effects with patients. Risks of brain surgery may include serious complications such as coma, intracranial hemorrhage, seizures and infection. Some of these risks may be fatal. Possible device complications include infection, problems with lead/extension connector positioning, parts wearing through the skin, or an interruption in therapy because of mechanical or electrical problems. Any of these situations may require additional surgery or cause symptoms to return. Some side effects associated with the stimulation may include worsening of tremor or speech and language impairments. Typically, these side effects are not permanent and can be resolved by adjusting stimulation parameters. Depression, suicidal thoughts, and suicide, have also been reported. Occurrence of “fall” has been observed in patients with Parkinson’s disease.

10. Benefits of Adding Medtronic DBS Therapy *Mean results; DBS is adjunctive to medications. 5. Activa Therapy Clinical Summary, 2009.

11. When Is Medtronic DBS Therapy Appropriate? Should be considered when the patient, despite optimal medical therapy, reaches a stage where the daily burden of PD begins to cause significant interference with: Daily function Occupational activities Important leisure time pursuits Basic activities of daily living Discuss each patient’s goals and expectations to determine whether DBS Therapy is right Set realistic goals about the benefits of Medtronic DBS Therapy

12. Medtronic DBS Therapy in the PD Continuum of Care In order to obtain maximum benefit, PD patients must be referred at the optimal time, or during a “window of opportunity” when DBS therapy may be most effective. Window of Opportunity Patient is experiencing troubling motor symptoms not effectively controlled by medications. “On” time characterized by disabling dyskinesias (or other nonmotor side effects) OR “Off” time characterized by disabling tremor, rigidity, or akinesia/bradykinesia OR Upredictable “on/off” motor fluctuations OR Medication-resistant tremor

13. Medtronic DBS Therapy Exclusion Criteria No longer responsive to dopaminergic medication Severely disabled even in the best “on” state Medical conditions that prevent surgery Onset of frank dementia

14. Medtronic DBS Patient Referral Advisor A tool that creates a patient “appropriateness” profile for DBS Therapy based on 5 absolute criteria and 7 relative criteria Clinical criteria and appropriateness ratings were developed by an expert panel of neurologists Software can be downloaded at: www.medtronic.com/dbsreferraladvisor

15. Patient Management Establish a partnership with an implant center to manage postimplant patient care, which involves: -Programming -Medical management

16. Device Programming Initial device programming: Identifying and programming optimal stimulation parameters during the first several months Maintenance device programming: Titrating stimulation as needed over time Patient programming is reimbursed

17. Innovative Programming Software Medtronic has developed technology to make device programming easier Features include: A step-by-step process that provides a systematic approach to programming The ability to capture, store and sort patient data in the device Functionality that maximizes therapeutic response and device longevity

18. Neuromodulation Therapies: Present Today, more than 500,000 patients globally have received Medtronic neuromodulation devices. 6 DBS Therapy continues to be the fastest growing treatment option for people suffering from movement disorders. More than 80,000 patients globally have been treated with Medtronic DBS Therapy 6. Medtronic, Inc. data on file.

19. Neuromodulation Therapies: Future The future of neurology will include the integration of device-based neuromodulation treatment into the management of the most common neurological disorders

20. Medtronic Neuromodulation Therapies PRESENT FUTURE Parkinson’s Disease Essential Tremor Dystonia* Obsessive-Compulsive Disorder* Chronic Pain (Opioid) Malignant Pain Spasticity Urinary Incontinence and Retention Intracerebroventricular (ICV) Applications Depression Chronic Migraine (ONS) Chronic Pain (Nonopioid) *Humanitarian Device: The effectiveness of this device for the treatment of dystonia or obsessive-compulsive disorder has not been demonstrated. Chronic Pain

21. Medtronic: The Leader in DBS Therapy Product innovation Education Procedure support Innovative clinical research Medtronic is committed to advancing the science of neuromodulation through:

22. Product Innovation Medtronic continues to offer new products such as –Activa ® PC: The next generation primary cell neurostimulator –Activa ® RC: The first rechargeable neurostimulator for DBS Therapy New programming platform provides step-by-step guidance and advanced device programming options

23. Innovative Clinical Research Medtronic has sponsored numerous studies to evaluate the safety and efficacy of Medtronic DBS Therapy for current and future indications More than 2,000 clinical papers have been published on DBS Therapy

24. Approved Indications for DBS Therapy Parkinson’s disease (FDA approved in 2002) Essential tremor (FDA approved in 1997) –AAN Guidelines state that unilateral DBS resulted in a significant (60% to 90%) reduction of contralateral limb tremor. 7 –DBS Therapy improves activities of daily living in patients with ET. 5 Dystonia (FDA approved HDE* in 2003) Obsessive-compulsive disorder (FDA approved HDE* in 2009) –The first psych indications approved for DBS * Humanitarian Device: The effectiveness of this device for the treatment of dystonia or obsessive-compulsive disorder has not been demonstrated. 5. Activa Therapy Clinical Summary, 2009. 7. Zesiewicz TA, Elble R, Louis ED, et al. Practice paramater: therapies for essential tremor: Report of the Quality Standards Subcommittee of the AAN. Neurology. 2005;64:2008-2020.

25. Medtronic DBS Therapy and Your Practice Step 1. Partner with your local implanting team. Establish referral processes and communications. Establish postimplant patient management roles. Step 2. Identify appropriate patients. Attend a Medtronic education program to learn more about appropriate patient selection. Use the DBS Therapy Patient Referral Advisor to confirm appropriateness for patient referral.

26. Medtronic DBS Therapy and Your Practice (continued) Step 3. Discuss DBS Therapy with patients and their caregivers. Discuss patients’ goals with them. Educate patients about the benefits and risks of DBS Therapy. Set appropriate expectations. Step 4. Refer appropriate patients for DBS Therapy.

27. Brief Disclosures Medtronic DBS Therapy for Parkinson ’ s Disease, Tremor, and Dystonia: Product technical manual must be reviewed prior to use for detailed disclosure. * Indications: Medtronic DBS Therapy for Parkinson ’ s Disease: Bilateral stimulation of the internal globus pallidus (GPi) or the subthalamic nucleus (STN) using Medtronic DBS Therapy for Parkinson ’ s Disease is indicated for adjunctive therapy in reducing some of the symptoms of advanced, levodopa-responsive Parkinson ’ s disease that are not adequately controlled with medication. Medtronic DBS Therapy for Tremor: Unilateral thalamic stimulation using Medtronic DBS Therapy for Tremor is indicated for the suppression of tremor in the upper extremity. The system is intended for use in patients who are diagnosed with Essential Tremor or Parkinsonian tremor not adequately controlled by medications and where the tremor constitutes a significant functional disability. The safety or effectiveness of this therapy has not been established for bilateral stimulation. Medtronic DBS Therapy for Dystonia: Unilateral or bilateral stimulation of the internal globus pallidus (GPi) or the subthalamic nucleus (STN) using Medtronic DBS Therapy for Dystonia is indicated as an aid in the management of chronic, intractable (drug refractory) primary dystonia, including generalized and segmental dystonia, hemidystonia, and cervical dystonia (torticollis), for individuals 7 years of age and older. Contraindications: Contraindications include patients who will be exposed to MRI using a full body radio-frequency (RF) coil or a head transmit coil that extends over the chest area, patients who are unable to properly operate the neurostimulator, or for Parkinson ’ s disease and Essential Tremor, patients for whom test stimulation is unsuccessful. Also, diathermy (e.g., shortwave diathermy, microwave diathermy or therapeutic ultrasound diathermy) is contraindicated because diathermy's energy can be transferred through the implanted system (or any of the separate implanted components), which can cause tissue damage and can result in severe injury or death. Diathermy can damage parts of the neurostimulation system. Warnings/ Precautions/Adverse Events: There is a potential risk of tissue damage using stimulation parameter settings of high amplitudes and wide pulse widths. Extreme care should be used with lead implantation in patients with a heightened risk of intracranial hemorrhage. Do not place the lead-extension connector in the soft tissues of the neck. Placement in this location has been associated with an increased incidence of lead fracture. Theft detectors and security screening devices may cause stimulation to switch ON or OFF, and may cause some patients to experience a momentary increase in perceived stimulation. Although some MRI procedures can be performed safely with an implanted DBS System, clinicians should carefully weigh the decision to use MRI in patients with an implanted DBS System. MRI can cause induced voltages in the neurostimulator and/or lead possibly causing uncomfortable, jolting, or shocking levels of stimulation. MRI image quality may be reduced for patients who require the neurostimulator to control tremor, because the tremor may return when the neurostimulator is turned off. Severe burns could result if the neurostimulator case is ruptured or pierced. The DBS System may be affected by or adversely affect medical equipment such as cardiac pacemakers or therapies, cardioverter/ defibrillators, external defibrillators, ultrasonic equipment, electrocautery, or radiation therapy. Safety and effectiveness has not been established for patients with neurological disease other than Parkinson ’ s disease or Essential Tremor, previous surgical ablation procedures, dementia, coagulopathies, or moderate to severe depression; or for patients who are pregnant, under 18 years, over 75 years of age (Parkinson ’ s Control Therapy) or over 80 years of age (Tremor Control Therapy). For patients with Dystonia, age of implant is suggested to be that at which brain growth is approximately 90% complete or above. Depression, suicidal ideations and suicide have been reported in patients receiving Medtronic DBS Therapy for Movement Disorders, although no direct cause and effect relationship has been established. Additionally, the abrupt cessation of stimulation for any reason should be avoided as it may cause a return of disease symptoms. In some cases, symptoms may return with an intensity greater than was experienced prior to system implant ( “ rebound ” effect). Adverse events related to the therapy, device, or procedure can include: stimulation not effective, cognitive disorders, pain, dyskinesia, dystonia, speech disorders including dysarthria, infection, paresthesia, intracranial hemorrhage, electromagnetic interference, cardiovascular events, visual disturbances, sensory disturbances, device migration, paresis/asthenia, abnormal gait, incoordination, headaches, lead repositioning, thinking abnormal, device explant, hemiplegia, lead fracture, seizures, respiratory events, and shocking or jolting stimulation. Humanitarian Device (Dystonia): Authorized by Federal Law for the use as an aid in the management of chronic, intractable (drug refractory) primary dystonia, including generalized and segmental dystonia, hemidystonia, and cervical dystonia (torticollis), for individuals 7 years of age and older. The effectiveness of this device for this use has not been demonstrated. USA Rx only Rev 0910

28. Brief Disclosure – Reclaim™ DBS Therapy for OCD Reclaim™ Deep Brain Stimulation Therapy for Obsessive-Compulsive Disorder: Product labeling must be reviewed prior to use for detailed disclosure of risks. Indications: The Medtronic Reclaim DBS Therapy is indicated for bilateral stimulation of the anterior limb of the internal capsule, AIC, as an adjunct to medications and as an alternative to anterior capsulotomy for treatment of chronic, severe, treatment-resistant obsessive-compulsive disorder (OCD) in adult patients who have failed at least three selective serotonin reuptake inhibitors (SSRIs). Contraindications: Contraindications include patients who will be exposed to MRI using a full body radio-frequency (RF) coil or a head transmit coil that extends over the chest area, and for patients who are unable to properly operate the neurostimulator. Also, diathermy (e.g., shortwave diathermy, microwave diathermy or therapeutic ultrasound diathermy) is contraindicated because diathermy’s energy can be transferred through the implanted system (or any of the separate implanted components), which can cause tissue damage and can result in severe injury or death. Diathermy can damage parts of the neurostimulation system. Transcranial Magnetic Stimulation (TMS) is contraindicated for patients with an implanted DBS System. Warnings/precautions/adverse events: Electroconvulsive Therapy (ECT) – The safety of ECT in patients who have an implanted deep brain stimulation (DBS) system has not been established. Induced electrical currents may interfere with the intended stimulation or damage the neurostimulation system components resulting in loss of therapeutic effect, clinically significant undesirable stimulation effects, additional surgery for system explantation and replacement, or neurological injury. There is a potential risk of tissue damage using stimulation parameter settings of high amplitudes and wide pulse widths. Extreme care should be used with lead implantation in patients with a heightened risk of intracranial hemorrhage. Do not place the lead-extension connector in the soft tissues of the neck. Placement in this location has been associated with an increased incidence of lead fracture. Theft detectors and security screening devices may cause stimulation to switch ON or OFF, and may cause some patients to experience a momentary increase in perceived stimulation. Severe burns could result if the neurostimulator case is ruptured or pierced. The safety of somatic psychiatric therapies using equipment that generates electromagnetic interference (e.g., vagus nerve stimulation) has not been established. The Reclaim DBS System may be affected by or adversely affect medical equipment such as cardiac pacemakers or therapies, cardioverter/ defibrillators, external defibrillators, ultrasonic equipment, electrocautery, or radiation therapy. Patients should be monitored for at least 30 minutes after a programming session, for side effects, including: autonomic effects (e.g., facial flushing, facial muscle contractions, or increased heart rate), hypomania, increased disease symptoms, sensations such as tingling, smell, or taste. In addition, during treatment, patients should be monitored closely for increased depression, anxiety, suicidality, and worsening of obsessive-compulsive symptoms. The safety and probable benefit of this therapy has not been established for patients with: Tourette’s syndrome, OCD with a subclassification of hoarding, previous surgical ablation (e.g., capsulotomy), dementia, coagulopathies or who are on anticoagulant therapy, neurological disorders, and other serious medical illness including cardiovascular disease, renal or hepatic failure, and diabetes mellitus. In addition, the safety and probable benefit has not been established for these patients: those whose diagnosis of OCD is documented to be less than 5 years duration or whose YBOCS score is less then 30, who have not completed a minimum of 3 adequate trials of first and/or second line medications with augmentation, who have not attempted to complete an adequate trial of cognitive behavior therapy (CBT), who are pregnant, under the age of 18 years, and who do not have comorbid depression and anxiety. Physicians should carefully consider the potential risks of implanting the Reclaim DBS System in patients with comorbid psychiatric disorders (e.g., bipolar, body dysmorphic, psychotic) as the Reclaim DBS System may aggravate the symptoms. Additionally, the abrupt cessation of stimulation for any reason should be avoided as it may cause a return or worsening (i.e., “rebound” effect) of disease symptoms. Serious adverse events related to the therapy, device, or procedure can include: suicidality/increased depression, increased OCD/fluctuating results, intracranial hemorrhage, lead/extension failure, aggression/violent behavior, accident proneness, irritability, death, hypomania, infection, pyelonephritis, and post-operative seizure. Adverse events related to the therapy, device, or procedure can include: coma, paralysis, pain or discomfort at incision/implant sites, general post-op discomfort, GI symptom (post op), increased anxiety, insomnia, cognitive disturbance (clouding), induced muscle contraction, restlessness, stimulation induced paresthesia, device migration, shocking or jolting stimulation, induced sensation of taste/smell, weight gain, increased fatigue, upper respiratory infection, headaches, dizziness, dry mouth, itching at surgical site(s), nausea, sedation, and weight loss. Humanitarian Device: Authorized by Federal (U.S.A) law for use as an adjunct to medications and as alternative to anterior capsulotomy for treatment of chronic, severe, treatment-resistant obsessive-compulsive disorder (OCD) in adult patients who have failed at least three selective serotonin reuptake inhibitors (SSRIs). The effectiveness of this device for this use has not been demonstrated. USA Rx Only Rev 1009