1. Latin American Section of the American Nuclear Society Symposium 2005 FDG Production at IEN/ CNEN - Rio de Janeiro, Brazil J.C.Suita

2. Instituto de Engenharia Nuclear Foundation: 1962 Foundation: 1962 280 employees today

3. /CNEN It occupies an area of 146.000m 2, in the Campus of the UFRJ, being 18.028m 2 of constructed area.

4. Main Activities Areas: Reactors Cornerstone of the Institute, the research reactor Argonauta is nowadays one of IEN's installations designed for experimental activities in physics and reactor engineering. Together with the nuclear and thermohydraulic measurement laboratories, it is used for the development of new applications in nuclear techniques; in supporting technical studies for the project, license and operation of nuclear installations, in the irradiation and sample analysis, as well as in personnel training, with post-graduate and specialization courses.

5. Instrumentation and Human Reliability IEN has developed more that 20 prototypes of spectrometry, radiation protection and nuclear medicine equipment during this period. The activities related to human reliability started with the Laboratório de Interfaces Homem/Sistema - LABIHS (Human/System Interface Laboratory), an installation that simulates the processes and the working environment in a nuclear plant control room.

6. Chemistry and Nuclear Materials The research, development and services related to chemistry conducted by IEN include the following activities: chemical and metallurgical processes, environmental technology, chemical analysis and material tests. The development of methodologies that use ultrasound techniques to evaluate residual tension in structures/components of nuclear reactors and others, as well as the efficiency of the measures taken to decrease tension, is an example of how advanced IEN is in the material characterization field.

7. Radiopharmaceutical Production CV 28 Cyclotron - 1974 RDS-111 Cyclotron - 2002

8. Radiopharmaceutical Production at IEN 123 I-NaI 123 I-MIBG 18 F-FDG DIRA/SERAD

9. Routine Production Weekly Schedule ! Irradiation: Sunday 04:00 - 07:00 pm Iodide Monday 08:00 am - 02:00 pm MIGB Tuesday 01:00 - 04:00 pmIodide ! Chemical Process: Monday 07:30 am - 10:00 am Iodide Tuesday 07:30 am - 11:30 amMIGB Wednesday 07:30 am - 10:00 amIodide ! FDG Production: Daily

10. Quality Control

11. Positron Emission Tomography - PET

12. New Instalations for FDG Production 18 O(p,n) 18 F E p = 11 MeV T 1/2 = 109 m Current: 40 µA

13. FDG Production System

14. Establishing a PET Radiopharmaceuticals Production Facility in colaboration with IAEA Double Hot Cells Automated Vial Dispenser Osmometer HPLC Gas Chromatography Leak Detector Dose Calibration Spare Parts from CTI

15. Production of 18 F - WITH CV- 28 CYCLOTRON Production of 18 F - WITH CV- 28 CYCLOTRON

16. FDG Production in Brazil S.Paulo - 2000Rio - 2003 Recife - 2007 BH - 2007

17. Thank you

18. I-123 Ultrapure 1996 - IAEA-FZK-IEN : Instalation of KIPROS system Xe(p,2n) Cs  Xe  I 124123 E p = 24 MeV T 1/2 = 13,6 h Current: 20 µA Yield: 3,5 mCi/µAh