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CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van.

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Presentation on theme: "CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van."— Presentation transcript:

1 CRISPR Immunity Relies on the Consecutive Binding and Degradation of Negatively Supercoiled Invader DNA by Cascade and Cas3 Edze R. Westra, Paul B.G. van Erp, Tim Künne, Shi Pey Wong, Raymond H.J. Staals, Christel L.C. Seegers, Sander Bollen, Matthijs M. Jore, Ekaterina Semenova, Konstantin Severinov, Willem M. de Vos, Remus T. Dame, Renko de Vries, Stan J.J. Brouns, John van der Oost Molecular Cell Volume 46, Issue 5, Pages 595-605 (June 2012) DOI: 10.1016/j.molcel.2012.03.018 Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

2 Figure 1 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

3 Figure 2 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

4 Figure 3 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

5 Figure 4 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

6 Figure 5 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

7 Figure 6 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

8 Figure 7 Molecular Cell 2012 46, 595-605DOI: (10.1016/j.molcel.2012.03.018) Copyright © 2012 Elsevier Inc. Terms and Conditions Terms and Conditions

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