1. 1 2 3 4 5 6 7 8 9 10 Activity © Snapshot Science, 2012Snapshot Science Spider image: Fir0002@ wikimedia commons Goat A Goat B Goat C Goat D (adult) Goat D

2. G F H I J B A Plenary © Snapshot Science, 2012Snapshot Science C D E The nucleus and silk gene is fused together. The egg is stimulated to divide to form an embryo. The milk of goat D contains the spider silk protein. Goat C gives birth to a transgenic goat (goat D) - it's DNA contains the spider silk gene. The egg cell from goat B and nucleus containing the silk gene are fused. The silk gene is cut out of the spider's DNA. The protein is extracted from the milk and spider silk is formed. An egg cell is taken from goat B and enucleated. A body cell is removed from goat A and the nucleus removed (enucleation). The embryo is put into the uterus of goat C.

3. Plenary © Snapshot Science, 2012Snapshot Science 1.What similarities are there between this process and adult cell cloning? 2.Are any of the goats clones? Explain your answer. 3.In the process a piece of DNA called a promoter is added to the start of the spider silk gene. This ensures that the gene is only expressed in the mammary gland cells of the goat. Why is this important? 4.Outline the ethical, economic and social arguments for and against this process.