1. 1 Coordinating and Financing R&D in Developing Countries-moving beyond PDP's The ANDI Experience Solomon Nwaka CEWG on R&D Financing & Coordination, April 6, 2011

2. 2 ANDI Vision "Creating a sustainable platform for R&D innovation in Africa to address Africa’s own health needs"

3. 3 ANDI touches 8 elements of the GSPOA 1.prioritizing research and development needs ; 2.promoting research and development ; 3.building and improving innovative capacity ; 4.transfer of technology ; 5.application and management of intellectual property; 6.improving delivery and access ; 7.ensuring sustainable financing mechanisms ; 8.establishing monitoring and reporting systems.

4. 4 Evolution of ANDI

5. 5 >500 people at ANDI Meeting Nairobi 2010

6. 6 Mapping & priority setting exercise supports ANDI establishment  Exploratory Research  Natural product / TM  Clinical  Marketing  Medicinal Chemistry  IP management  Regulatory  Manufacturing  Pre-clinical toxicology  Safety / pharmacology  API production

7. 7 SOURCE: Thomson Web of Science  Cities with 30 or more articles published in the 2004 - 08 period  Total of 90 cities in 27 countries  16,647 biomedical articles led by African authors included in analysis Note: Only top 40 cities by research output labeled Competency research centers exist

8. 8 R&D collaborations biased externally e.g. HIV/AIDS SOURCE: Thomson Web of Science, UCINET

9. 9 SOURCE: Delphion, VantagePoint, UCINET Patent activity also biased externally

10. 10 WHA62.16, 2009: "ANDI is a key initiative aimed at supporting and promoting African led health product innovation…." AMCOST, 2010: "AMCOST welcomes…African Network for Drugs and Diagnostics Innovation (ANDI) and its anticipated contribution to the science, technology and innovation……'' ANDI approach has received political recognition

11. 11 Governance  Hosting Agency – UNECA  Board – Co-Chaired by: Minister Mugo of Kenya (Health) Minister Pandor of South Africa (S&T) – 12 members with >75% from Africa – WHO, AfDB, UNECA  Secretariat – Operates through regional hubs Fund

12. 12 ANDI business model – network-based projects

13. 13 ANDI's IT platform - open access and secure components

14. 14 Technical progress & challenges – Centres of Excellence for health innovation in Africa being identified (public & private) Call resulted in 130 applications being reviewed – Call for projects resulted in 207 project applications Projects being reviewed & prioritized for funding – Key challenge is: $$$$$$$ EU have provided seed funds

15. 15 Financing options  Trust Fund at UNECA – Seeking to grow to $30M p.a. in regular contributions in 5 years – Actively fund raising  Exploring – Additional Trust Funds with other partners – Endowment Fund  Potential to leverage financing for projects / infrastructure – National Resources (public and private) – Governments and development agencies – Development and trade banks – Foundations and others …….

16. 16 One measure of success in 5 - 10yrs

17. 17 Lessons learned through ANDI  Desire for regionally coordinated / facilitated approach – Support at technical, business and political levels important  Address interface between research and market access early – Local product manufacture, regulatory and IP issues  Need for alignment between public and private sectors – Interest from governments, development and private banks  Link to Regional Science, Technology and Innovation policies – Support for SMEs, manufacture and commercialization  R&D financing should consider ALL these opportunities and the potential power of catalytic financing and leverage at local level

18. 18 Future coordinating role may be required