1. Office of Science Education National Institutes of Health Department of Health and Human Services Introduction to the National Institutes of Health

2. DHHS Agencies Administration for Children and Families (ACF) Administration on Aging (AoA) Agency for Healthcare Research and Quality (AHRQ) Agency for Toxic Substances & Disease Registry (ATSDR) Centers for Disease Control (CDC) Centers for Medicare and Medicaid Services (CMS) Food and Drug Administration (FDA) Indian Health Service (IHS) National Institutes of Health (NIH) Program Support Center (PSC) Substance Abuse & Mental Health Administration (SAMHSA)

4. NIAID Hamilton, MT NIH Bethesda, MD NIEHS Raleigh/Durham, NC NIDDK Phoenix, AZ NIA, NIDA Baltimore, MD NIH Bethesda, MD NIEHS Raleigh/Durham, NC

5. Frederick, MD Baltimore, MD Bethesda, MD Frederick, MD Baltimore, MD Bethesda, MD

6. National Institutes of Health Bethesda, MD

7. The NIH has 75 buildings on 322 acres in Bethesda, Maryland

8. NIH Mission Statement NIH is the steward of medical and behavioral research for the Nation. Its mission is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. The goals of the agency are as follows: 1) foster fundamental creative discoveries, innovative research strategies, and their applications as a basis to advance significantly the Nation's capacity to protect and improve health; 2) develop, maintain, and renew scientific human and physical resources that will assure the Nation's capability to prevent disease; 3) expand the knowledge base in medical and associated sciences in order to enhance the Nation's economic well-being and ensure a continued high return on the public investment in research; and 4) exemplify and promote the highest level of scientific integrity, public accountability, and social responsibility in the conduct of science.

9. National Institutes of Health Organized into an Office of the Director & 27 Institutes and Centers 18,000+ employees Budget FY200327.173 Billion FY200428.028 Billion FY2005 28.757 Billion (President’s Budget)

10. = Extramural only NEI NCI NHLBI NLMNINDS NIMH NIAMS NINR NCCAM CIT CC NHGRI NIA NIAAA NIAID NICHD NIDCD NIDCR NIDDK NIDA NIEHS OD NIGMSNCRR NIBIBNCMHD FIC CSR NIH consists of 27 Institutes and Centers

11. The mission of the NIH is to uncover new knowledge that will lead to better health for everyone by: conducting research in its own laboratories (intramural) providing support for research conducted by scientists in universities, medical schools, hospitals, and other research institutions throughout the country and abroad (extramural) training research investigators fostering the communication of medical information National Institutes of Health

12. Research Grants 71% All Other 6% Research Management & Support 3% Intramural Research 10% R&D Contracts 7% Research Training 3% (FY 2001 $20.3 billion) Over 80% of NIH funds support extramural research National Institutes of Health Budget

13. The world’s largest hospital devoted exclusively to clinical research. 250 beds 7,000 inpatient admissions a year 9,750 new patients a year 72,600 outpatient visits a year 1,200 physicians, dentists, and doctoral-level researchers 900 active clinical research protocols Warren Grant Magnuson Clinical Center

14. Opened September 2004 Mark O. Hatfield Clinical Research Center

15. postbaccalaureate trainees medical students graduate students postdoctoral and clinical fellows summer students (high school, college, graduate, and medical) tenure-track investigators senior investigators 230 93 160 3,300 1,000 287 919 (2001 data) How many researchers are at NIH?

16. Marshall W. Nirenberg, Ph.D., NHLBI (1968) Translated the genetic code of DNA and explained how it functions in the production of protein in the cell Julius Axelrod, Ph.D., NIMH (1970) Discovered the regulation of neurotransmitters, chemicals involved in nerve cell communication, leading to therapies for disorders like depression Christian B. Anfinsen, Ph.D., NIAMS (1972) Determined the relationship between the sequence of amino acids in proteins and their 3D structure Nobel Laureates in the NIH Intramural Program

17. D. Carleton Gajdusek, M.D., NINDS (1976) Identified so-called slow viruses (now known as prions), which cause neurodegenerative diseases, and their mode of transmission Martin Rodbell, Ph.D., NIEHS (1994) Discovered “G” proteins which trigger a cell’s response to outside signals, involved in normal activities and in diseases like cancer and cholera Nobel Laureates in the NIH Intramural Program (Cont’d)

18. Joseph L. Goldstein, M.D. and Michael S. Brown, M.D. Paul J. Thomas Professors of Medicine and Gentetics, University of Texas Health Science Center at Dallas, Nobel Laureates Philip Leder, M.D. John Emory Andrus Professor of Genetics at Harvard Medical School Harold E. Varmus, M.D. Director, Memorial Sloan-Kettering Cancer Center, Nobel Laureate, and former director of the NIH Distinguished scientists who trained at NIH

19. Francis S. Collins, M.D., Ph.D. Contributions to the success of the Human Genome Project Anthony S. Fauci, M.D. Award-winning research, recognized for his seminal research into AIDS and other immune system diseases NIH scientists in the news

20. www.nih.gov