1. US TOO INTERNATIONAL, INC US TOO GREATER QUAD CITIES PROSTATE CANCER SUPPORT GROUP

2. The Anatomy

3. STATISTICS:PROSTATE CANCER The prostate is the #1 Cancer site in men 220K men are diagnosed each year The number of new prostate cancer cases will rise sharply as the “Baby Boomers” come of age 29K men die of prostate cancer each year (down from 40K men that used to die each year before DRE and PSA screenings were used AFRICAN-AMERICAN men have prostate cancer death rates over twice those of Caucasians (53.7/100K men VS. 24.1/10K)

4. 1 in 6 men will develop Prostate Cancer Each person w/ Prostate CA is someone’s father, uncle, brother, son, etc. With early detection, prostate cancer has an 85- 95% cure rate In early stages, treatments are far less traumatic

5. Relationship of the PSA Level to the Prevalence of Prostate Cancer and High-Grade Disease PSA Level# of menMen withMen with hi-grade (N=2950)Prost. CA Prost. CA (N=449) (N+67) 0 - 0.5 ng/ml 496 32(6.6) 4/32 (12.5) 0.6-1.0 ng/ml 791 80 (10.1) 8/80 (10.0) 1/1-2/0 ng/ml 998170 (17.0) 20/170 (11.8) 2.1-3.0 ng/ml 482115 (23.9) 22/115 (19.1) 3.1-4.0 ng/ml 193 52 (26.9) 13/52 (25.0) * High-grade disease = Gleason score > 7. PSA < 4.0 ng/ml. Reproduced with permission from: Thompson, M, Pauler, DK, Goodman, PJ, et al. N Engl J Med 2004; 350:2239. Copyright C 2004 Massachusetts Medical. Prevalence of prostate cancer among men with a prostate-specific antigen level >4.0 ng

6. Prostate cancer is NOT just an old man’s disease! Literature on prostate cancer usually states that older men in their 60s or 70s are more likely to get the disease. More men in their late 40s and early 50s are being diagnosed with prostate cancer.

7. SYMPTOMS: PROSTATE CANCER NO SYMPTOMS (EARLY STAGE CA) Blood in urine Pain or difficulty urinating Increased frequency of urination, often at night Increased urgency to urinate Inability to urinate Pain/discomfort in area of prostate (near rectum) Unexplained weight loss Unusual, persistent bone pain (usually spine)

8. PROSTATE CANCER: THE GENETIC LINK NO FAMILY HISTORY OF CANCER (CA) FAMILY HISTORY OF CA OTHER THEN PROSTATE BOTH PARENTS W/ CA OTHER THEN PROSTATE DAD w/ PROSTATE CA, MOM w/ OTHER CANCER FATHER AND UNCLES(S) WITH PROSTATE CA GRAMPA, DAD & UNCLE(S) HAD PROSTATE CA 1 in 9 (11.2%) 2 in 9 (18.9%) 2 in 5 (42.6%) 1 in 2 (53.1%) 3 in 5 (61,7%) 4 in 5 (86.3%)

9. PROSTATE CANCER SCREENING RECOMMENDATIONS

10. WHO SHOULD BE SCREENED? WHO SHOULD BE SCREENED? Men over 40 w/ risks: Annual DRE &PSA (African American or w/ family history) All men by age 45: Annual DRE & PSA

11. THE “MAN-O-GRAM”

12. The DRE

13. THE BENEFITS OF SCREENING Peace of mind! Catching prostate CA early Improving your odds of surviving Detecting CHANGES in PSA

14. PSA: WHAT YOU SHOULD KNOW PSA stands for Prostate Specific Antigen All men should get a baseline PSA by age 45, then annually thereafter All men should know their PSA number Men should keep track of changes in their PSA # over time Don’t accept this answer from your Dr: “Your PSA is normal”

15. WHAT IS A “GOOD” PSA READING? One that stays CONSTANT! An increase of 25% in one year means you should get checked again in 6 months If PSA continues to rise sharply, get biopsy

16. PROSTATE CANCER TREATMENT OPTIONS RADICAL PROSTATECTOMY –Perineal –Retropubic* –Laproscopic* *Nerve Sparing Procedures

17. PROSTATE CANCER TREATMENT OPTIONS RADIATION THERAPY External Radiation –IMRT: Intensity-Modulated Radiation Therapy –Conformal Radiation –3-D Radiation –Proton Beam Radiation

18. PROSTATE CANCER TREATMENT OPTIONS BRACKYTHERAPY (Internal Radiation) –Paladium Seeds –Iodine Seeds –High Dose Therapy

19. PROSTATE CANCER TREATMENT OPTIONS Hormone Therapy Cryotherapy Thermal Therapy Watchful Waiting

20. WHAT YOU NEED TO KNOW ABOUT PROSTATE CANCER If you have a family history, include DRE and PSA in your annual checkups Get to know your PSA numbers (make sure your PSA numbers are stable)

22. IF YOU HAVE PROSTATE CA Know your PSA numbers Know your Gleason Score Find a support network or group to get unbiased info on treatment options