2. Herpesviridiae Crista Wagner

3. Herpesviridae Taxonomy Baltimore FAMILY I 2XDNA  mRNA directly enveloped Greek herpein "to creep" infection creeps latency  acute >130 genera Varicellovirus: chicken pox & shingles Cytomegalovirus: immunocompromised individuals Simplexvirus: oral & genital herpes

4. Simplexvirus Characteristics human host, no animal reservoir 60–95% of adults transmitted via infected secretions causes painful necrotic lesions herpes simplex encephalitis latent infection course acute in epithelia, self-limiting ~14d latent in neurons recurrence triggered by various factors

5. Simplexvirus Reproduction

6. HSV Infection of the Neonate 1/2000 infected during birth, 3/4 to asymptomatic mothers Prevention: MOB acyclovir, caesarean delivery SEM: 45% of cases, mortality rate 0% skin, eye and mouth lesions  CNS or DIS CNS: 30% of cases, mortality rate 4% central nervous system (encephalitis) lethargy, fever, seizures, neurological dysfunction, brain destruction DIS: 25% of cases, mortality rate 29% disseminated to multiple organ systems: liver & lungs lethargy, fever, pneumonia, liver dysfunction, coagulopathy PCR for viral DNA, 14–21d IV acyclovir

7. My Questions and Answers Question: Where are Simplexvirus during latent infection? Answer: sensory neurons No, no. Never, never do you want to have this slide as part of your presentation!!! Also…the answer is more detailed than what you said in your presentation!

8. Herpesviridae Characteristics Baltimore Group I 2XDNA  mRNA directly over 130 genera infect animals or humans enveloped latent infection course latent in neurons acute in epithelia Instead, try something subtle…

9. Things to Remember Dark background with white text is easier to see. Background designs can be distracting. More than ten words across the slide means your type is too small to be read. Too many words on the slide means you’re being ignored and everyone is just reading. Five minute presentations should have more than 7 slides. More than that, you’ve probably got too much information to finish on time.