1. Page 1 An Academic Health Sciences Centre at the heart of a world city....

2. Page 2 The partners – four highly-performing institutions each bringing complementary and distinctive contributions Hillingdon Harrow Ealing Brent Barnet Enfield Haringey Camden Hounslow Richmond Wandsworth Kingston Merton Sutton Croydon Bromley Lewisham Lambeth Southwark Greenwich Westminster Ken. & Chel. City Tower Hamlets Newham Hackney Islington Waltham Forest Redbridge Havering Barking Bexley Hammersmith ’ ’ - Excellence in clinical service Comprehensive portfolio of excellent quality innovative services International recognition: in renal and liver disease, dermatology, haematology, children’s, neurosciences, foetal medicine and mental health Excellence in research One of top 5 biomedical research universities in UK (2008 RAE) Six MRC Centres, three NIHR Research Centres and BHF Centre of Excellence Institute of Psychiatry and SLaM leading mental health research centre in Europe Excellence in education Unique breadth of education and training to 9,500 students At the forefront of innovation and exploiting new technology Capacity building for translational research Four high-performing institutions Guy’s and St Thomas’ (GSTT) King’s College Hospital (KCH) South London and Maudsley (SLaM) King’s College London (KCL)

3. Page 3 Collaboration – working to make London a leading ‘healthcare city’ Hillingdon Harrow Ealing Brent Barnet Enfield Haringey Camden Hounslow Richmond Wandsworth Kingston Merton Sutton Croydon Bromley Lewisham Lambeth Southwark Greenwich Westminster Ken. & Chel. City Tower Hamlets Newham Hackney Islington Waltham Forest Redbridge Havering Barking Bexley Hammersmith South East Established networks across South East (e.g. Cancer and Neurosciences) Working to establish Health and Innovation Clusters across Southern England London Substantial collaboration already (e.g. Allergy and Environment and Health) Three AHSCs working closely together to make London one of the world’s leading centres of healthcare UK Founder member of Global Medical Excellence Cluster (GMEC) Will partner with the UK Centre for Medical Research and Innovation (MRC) International Existing collaborations and relationships (e.g. Johns Hopkins, UNC, UCSF, Somaliland, Zambia) Maudsley International

4. Page 4 Strategic priorities – existing excellence, emerging strengths ● Neuroscience, Neurological Disease and Mental and Behavioural Disorders ● Cardiovascular Disease, including Imaging ● Asthma, Allergy, Environment and Health ● Oral Disease / Dentistry ● Transplantation, Regenerative Medicine / Stem Cells ● Dermatology ● Medical Genetics ● Diabetes, Obesity and Metabolic Disease; Healthy Living ● Cancer, including Palliative Care and Cancer Imaging Emerging strengths of relevance to the local population Existing comprehensive international profile, excellence in research and clinical service delivery

5. Page 5 The population – focus on local health needs and reducing inequalities Health Indicator Source : Department of Health Community Health Profiles 2008 Key Worse than London average In line with London average Better than London average LambethSouthwarkLewishamGreenwichCroydonBromleyBexley Binge drinking adults Deaths from smoking Drug Misuse Early deaths: Cancer Early deaths: Heart disease & stroke Healthy eating adults Hospital stays due to alcohol Infant Mortality Life expectancy Mental Illness Obese Adults Obese Children Physically active adults Teenage Pregnancy Tuberculosis Violent Crime

6. Page 6 The vision – a radical change in healthcare To advance health and well-being by integrating world-class research, care, education and training through: ● Translating research more rapidly into clinical practice and effectively disseminating these advances through education and training ● Harnessing the power of discovery science to transform the nature of healthcare by moving from treatment towards population screening and disease prevention ● Recognising the special needs and inequalities in health among the local population and addressing these through earlier intervention and personalised medicine, as well as helping local people to maintain, improve and enhance their health

7. Page 7 Cardiovascular Dementia and Older People’s Mental Health Diabetes and Obesity Other Clinical Academic Groups The structure – Clinical Academic Groups All clinical services and translational research Strategy for delivery of the tripartite mission Devolved budgets The key building blocks of the AHSC CLINICAL ACADEMIC GROUPS

8. Page 8 The structure – accelerating translation and disseminating knowledge Basic Sciences Institute NIHR Biomedical Research Centres Health Service Research And Evaluation Research And Innovation Services Drive basic discovery Drive translation Evaluate Efficient infrastructure to deliver translation Disorder / Research Based Training and Education EDUCATION ACADEMY Disorder- / Research-based training and education Disseminate knowledge, train the next generation Cardiovascular Dementia and Older People’s Mental Health Diabetes and Obesity Other Clinical Academic Groups CLINICAL ACADEMIC GROUPS

9. Page 9 Partnership Board AHSC Executive Basic Sciences Institute NIHR Biomedical Research Centres Health Service Research And Evaluation Research And Innovation Services Drive basic discovery Drive translation Evaluate Efficient infrastructure to deliver translation The structure – integrating leadership and linking resources to the vision Cardiovascular Dementia and Older People’s Mental Health Diabetes and Obesity Other Clinical Academic Groups CLINICAL ACADEMIC GROUPS Disorder / Research Based Training and Education EDUCATION ACADEMY Disorder- / Research-based training and education Disseminate knowledge, train the next generation KCLGSTTKCHSLaM

10. Page 10 Cardiovascular CAG – added value of the AHSC Clinical innovation Non-invasive aortic valve replacement delivered jointly across GSTT and KCH Primary PCI – first 24/7 programme in UK, pilot site for the DH, 400 patients p.a. MR-guided cardiac catheterisation N.B. for electrophysiology Research Integration of basic science and clinical programme e.g. ischaemia reperfusion, cytoprotection, novel interventions monitored by MR Education and Training Dissemination of best practice to local networks and beyond Prevention Public education to raise awareness / access Ethnicity and risk Non-invasive diagnosis of EC dysfunction Targeted early intervention

11. Page 11 What will be different? Shorter translational pathways We will: ● Work with partners in our local communities to identify ill-health at the earliest possible opportunity ● Train all of our nurses to ensure that every patient has the opportunity to grant their consent to participate in research during their first contact ● Build on the CRIS IT system to optimise the ability to utilise the clinical patient record to support research ● Create a biobank to inform research through taking samples during treatment from all consenting patients Ultimately: ● Providing the best and most up-to-date treatments and the best service delivered consistently by the best trained staff in the most appropriate setting to ensure the best outcomes for all of our patients

12. Page 12 What will be different? Benefits for patients Future Now Four independent organisations with different visions and investment priorities Partnership with integrated leadership, shared purpose and investment priorities Lack of integration of clinical, research and education due to organisational barriers CAGs responsible for developing and delivering the tri-partite mission Long translational cycle time with low levels of patient participation in research Shorter translational pathways delivered through our new research infrastructure Slow adoption of innovation and best practice locally, nationally, internationally Faster and wider dissemination of knowledge through the Education Academy Focus of clinical and academic resources on treating ill-health in a hospital setting Increased resources invested in prevention and on delivering care in the community General poor health of our local population with wide inequalities in health and access Reduced inequalities, better health through most up-to-date treatments to patients