1. Alternative Careers in Pharma and Biotechnology Douglas Buckley Ph.D. May 13, 2011 Alternative Career Symposium Baylor College of Medicine

2. Outline Company organization Scientific roles in various divisions Jobs that span the continuum Impacts of organization size Brief notes on the job search Keys to success in industry

3. Company Organization Research – Target discovery and validation Discovery – Target prosecution, NCE development Development – IND through Ph. III activities Commercial Ops – Product manufacturing, QC, distribution and logistics Marketing – Pricing, advertising, competitive positioning, physician support, patient support Research Discovery Development Commercial Ops Commercial Ops Marketing

4. Scientific Roles in Divisions Research Focus is on target identification and validation Team may be self-contained or matrixed Team may include: Cell Biology Genetics Genomics Protein Sciences Pharmacology Deliverable is a screen-ready target

5. Scientific Roles in Divisions Discovery Focus is on pharmaceutical discovery Team is generally matrixed Team may include: High-throughput screening Cell Biology Medicinal Chemistry or Protein Engineering Genomics Crystallography ADME Pharmacology and Toxicology Deliverable is an IND-ready product

6. Scientific Roles in Divisions Development Focus is on moving product through clinical trials Team is generally matrixed Team includes: Clinical Research and Clinical Sciences Pharmacology and Toxicology Biostatistics, Programing, and Data Management Process Development Formulations Clinical Operations Regulatory Affairs Deliverable is a New Drug Application (NDA)

7. Scientific Roles in Divisions Commercial Operations Focus is on assuring drug supply to the patient Team is generally matrixed Team includes: Manufacturing Quality Control and Quality Assurance Logistics Regulatory Affairs Deliverable is an uninterrupted drug supply

8. Jobs That Span the Continuum Translational Medicine Companion Diagnostics Medical Writing Project and Program Management Alliance Management Business Development Legal Services

9. Don’t forget – CROs do all of these jobs too!

10. Impacts of Organization Size Large Pharma Hire for a specific role Mentoring more available Organizational rigidity Higher bureaucratic load Higher salaries Small Start-up Premium placed on flexibility Learn as you go Rapid change and adaptation Fast decisions, many mistakes Equity participation

11. Notes on the Job Search Network, Network, Network! PI Collaborators Past grad students and post-docs You are always in the job search Seminars Meetings and poster sessions Social situations and elevators Work on your 30-second drill Two minutes in the hallway with a smartphone can make you informed rather than clueless!

12. Keys to Success in Industry Know what success looks like to your boss Doing exceptional work at your current job opens the door to new opportunities Train your successor in order to be able to move out of your current position Ask your boss, your peers, and your subordinates what you need to do to improve Actively communicate Acknowledge the contributions of others Be nice to the Administrative Assistants!

13. Thanks to all of my mentors and colleagues!