1. | www.genzyme.com Jade (with her mother) Fabry disease USA Welcome Doherty Memorial High School Genzyme Center November 1, 2012

2. 2 Jannan Multiple Sclerosis USA Our mission is to discover and deliver transformative therapies for patients with rare and special unmet medical needs, providing hope where there was none before.

3. Focused on rare diseases and multiple sclerosis (MS) 6 major marketed products 10,000 employees worldwide Founded in 1981 and pioneered treatments for rare diseases David Meeker, MD, CEO About Genzyme 3

4. Our Global Commitment 4 Headquartered in the U.S. with global locations in over 40 countries Expanding manufacturing capabilities in the U.S. and E.U. Collaborating with patient communities, physicians, universities, hospitals, charitable organizations, companies globally Serving patients in over 100 countries

5. Genzyme, a Sanofi company In April 2011, Genzyme became a wholly owned subsidiary of Sanofi We benefit from the reach and resources of one of the world’s largest pharmaceutical companies Sanofi’s portfolio of products includes: prescription medicines, vaccines, generics, consumer health care, and animal health 110,000 employees worldwide 5

6. Patients are at the heart of what we do 6 Science Manufacturing & Distribution Government Affairs Regulatory Advocacy & Access Legal, HR, Communications Sales & marketing

7. Anisa MPS I disease Avery Fabry disease Eulacio Children Gaucher disease Melanie Multiple Sclerosis Fida Pompe disease Thomas FH Joan Thyroid Cancer

8. A lifetime commitment 8 “My mom was just tremendous and an amazing role model for me. I know the doctors told her that I was going to die but her perseverance, dedication and ability to work closely with Genzyme and search around the world to develop a treatment was amazing.” – Brian Berman, Gaucher disease type 1 1983199120012011

9. Cardiovascular Late-stage treatment for Familial Hypercholesterolemia (FH) Genzyme’s Business Units Rare Diseases Multiple Sclerosis Genetic Diseases One oral marketed product and One late-stage infusion treatment Endocrinology Gaucher disease type 1, Fabry disease, Pompe disease, MPS I disease Facilitating thyroid cancer treatment and testing 9

10. 10 Driven by Science Genzyme R&D Center Broad range of technology platforms Closely integrated with clinical, commercial, regulatory, patient advocacy Dedicated to pursuing unmet medical needs Highlights Research in Parkinson’s, Niemann-Pick, Lupus, and Cystic Fibrosis Next-generation therapies for Gaucher, Pompe, and Fabry diseases

11. 11 School Science Program Waterford, Ireland Community Involvement: Employee volunteerism, support for science education and health initiatives Humanitarian Programs: Free drug programs Environmental Initiatives: Green buildings and greenhouse gas reduction efforts Our Responsibility

12. Genzyme Center - Today How did we get here and why?

13. Genzyme: The Beginning - 1981 Kneeland Street, Boston A company that cares about Patients Employees

14. Genzyme’s Headquarters 1990-2003 One Kendall Square Cambridge, MA

15. Brownfield Site - Cambridge, MA A Brownfield site is an industrial site that has ground contamination −plant that turned coal into gas (a coal gasification plant) Developer bought 10 acre site for $21 million Cost to remediate site from contaminants - $198 million

16. Remediation of Brownfield Site

17. Committed to the Community 192520002003 Principal architectBehnisch Architects, Germany Construction managersTurner Construction DevelopersLyme Properties Square footage350,000 sq. ft. OccupancyNovember 2003; ~950 employees

18. Anchor of Mixed Use Development

19. Considerations for New World Headquarters Location Size Cost Comfort of Employees Recruitment & Retention The Environment −Building Materials Company Culture

20. Reflecting Corporate Values in the Building DriveInnovationIntegrityCollaborationEntrepreneurialismCompassion Core Values - INNOVATION COLLABORATION TRANSPARENCY

21. The Concept of Genzyme Center Reflective of Genzyme’s core values Designed from the inside out Productive and collaborative workspace Environmentally responsible and energy-efficient

22. United States Green Building Council Genzyme Center received Platinum LEED rating −Leadership in Energy & Environmental Design −The highest rating of the United States Green Building Council −Rating is based on: − Sustainable site design − Materials selection − Energy use − Water conservation − Indoor environmental quality

23. Site Selection, Design & Indoor Environmental Quality Restored Brownfield site Living roof: heat reduction, rainwater run-off reduction White roof to reduce “heat island effect” Direct view of the outdoors from 90% of work spaces 18 themed interior gardens

24. Material Selection Recycled 93% of construction waste 23% of materials used in building are recycled material (concrete, steel, aluminum, tile, drywall, ceilings, carpets) More than 60% materials from local sources Wood materials from managed forests Recycled content carpet squares Concrete filigree slab construction

25. Energy-Efficient Features Concrete slab construction Insulating “loggia” 800+ operable windows Solar panels −Produce 1% of Genzyme Center’s electricity Waste steam used for heating and cooling, efficient systems, building control, use of natural ventilation Use of “green” power from renewable source

26. Water Conservation High efficiency irrigation using soil sensors Rainwater run-off collection systems Low flow fixtures – waterless urinals, dual flush toilets 525,000 gallons per year saved Lobby floor water feature / reflecting pool

27. Natural Light Enhancement Systems

28. Soaring 12-story atrium

29. Natural Light Enhancement Systems All glass exterior Heliostats on roof

30. Natural Light Enhancement Systems Skylight and louvered sunshades

31. Natural Light Enhancement Systems Chandelier −Prismatic tiles

32. Natural Light Enhancement Systems “Light wall” of polished aluminum strips Reflecting pool

33. Natural Light Enhancement Systems Computer controlled blinds Reflective Ceiling Panels

34. Ceiling Design Inspired by Matisse’s Blue Nude

35. Ceiling Design

36. Genzyme Green Buildings - LEED Registered and Certified 2005: Genzyme Center: NC: Platinum 2007: 675 West Kendall: CI: Silver 2008: Framingham Science Center: NC: Gold 2009: Ridgefield: NC: Gold 2010: Lyon: HQE Certified (and LEED) 2010: Phoenix: CI: Silver 2010: Allston: NC Gold 2010: Waterford: NC Gold 2010: San Antonio: EB Silver 2011: Ridgefield: CI: Platinum 31 New York Avenue 68 New York Avenue Northborough Distribution Center Geel, Belgium Framingham Science Center, 49 New York Avenue Lyon, France Manufacturing Plant LEED NC: new construction CI: commercial interior EB: existing building HQE: High Environmental Quality (French Standard)

37. Questions? Thank You