1. Principles of Immunology Overview of Innate Immunity 1/19/06
“Education is not preparation for life. Education is life itself.”
John Dewey

2. Review(T/F) Jenner was the first to introduce variolation
Innate immune responses are specific
T cells are either T-helper or T-cytotoxic cells
Immunological memory results in an amanestic response
All antigens are immunogens

3. Innate Immunity
Nonspecific host defenses that exist prior to exposure to an antigen. Involves the following components:
Anatomic
Physiologic
Phagocytic
Inflammatory

4. Word List Antibody Antigen Complement Endocytosis Humoral Macrophage
Monocyte
Neutrophil

5. Barriers to Antigenic Insult
Anatomic
Skin
Mucous membranes
Physiologic
Temperature pH
Chemical mediators

6. Cellular and Inflammatory Components of Innate Immunity
Phagocytic cells
Inflammatory
Vasodilation
Capillary permeability

7. Anatomic Barriers Skin Epidermis Dermal layer Sebaceous glands
Normal flora

8. Anatomic Barriers Mucous membranes Physical barrier Secretions Cilia
Normal flora

9. Physiologic Barriers Temperature pH Varies by species Febrile response
Endogenous pyrogens pH
Skin
GI tract

10. Physiologic Mediators of Innate Immunity
Chemical mediators
Enzymes
Interferon
Complement
Three pathways
Classical
MB Lectin
Alternative

11. Physiologic Mediators of Innate Immunity(cont’d)
Chemical mediators
Collectins
Toll-like receptors
Acute phase proteins

12. Cellular Component of Innate Immunity
Phagocytic cells
Monocytes
Neutrophils
Macrophages
Non-Phagocytic cells
Natural killer cells

14. Inflammatory Response
Hallmarks of inflammation
Rubor
Tumor
Calor
Dolor
Primary cell
Activated macrophage

15. Inflammatory Response(cont’d)
Biological effects
Vasodilation
Capillary permeability
Phagocyte migration

17. Inflammatory Response(cont’d)
Chemical mediators of inflammation
Histamine
Kinin system
Fibrin system