1. Gastric Secretion Johnson Chap. 34-35 Jack L. Leonard 2004

2. Johnson Chap. 34-35 The Stomach Esophagus Fundus Corpus Pyloric antrum Pyloric canal Pylorus Duodenum Gastric pit isthmus neck base Parietal cells Surface mucous cells Mucous neck cells Argentaffincell Chief cells

3. Johnson Chap. 34-35 The Pavlov Pouch Experiment

4. Johnson Chap. 34-35 0.6 0.4 0.2 0 1 230 hours Acid Output (mmol/15min) jejunum Heidenhain pouch Double-walled muscosal septum Vagally innervated pyloric pouch A. B. Incision Closure Pouch sham feeding

5. Johnson Chap. 34-35 Acid Output (mEq T.A./7.5 min) Time (min) Histamine Stimulation of Acid Secretion

6. Johnson Chap. 34-35 Basal folds Basement lamina lamina Golgi TubulovescularMembrane Intracellularcanaliculus Mitochondria Basal folds Unstimulated Intracellularcanaliculus Mitochondria Intracellularcanaliculus TubulovescularMembrane Basement lamina lamina Stimulated Changes in Parietal Cell Morphology with Stimulation

7. Johnson Chap. 34-35 Ion Transport in the Parietal Cell

8. Johnson Chap. 34-35 Presumed Effects of Stimuli on the Parietal Cell Vesicles ATP ADP+ PO 4 K+K+K+K+ H+H+H+H+ K+K+K+K+ K+K+K+K+ Cl - P H/K J Cl JKJKJKJK

9. Johnson Chap. 34-35 Stimulation Presumed Effects of Histamine on the Parietal Cell