2. MDARD notified of turkey mortalities at large turkey and swine integrated farm Cause of death unknown Turkey mortalities at processor (USDA notified) Turkeys and feed samples sent to MSU for analysis feed forwarded to IN Office of the State Chemist Necropsy Finding: lasalocid toxicity Feed Analysis: lasalocid 5X labeled rate

3. Animal Drug Approved for use in poultry, cattle & sheep feeds Avatec and Bovatec Used to prevent coccidiosis in poultry Turkeys fed at a rate of 68 – 113 g/ton

4. Who makes the feed? On farm mixer / feeder Commercial feed mill Farm uses lasalocid in turkey feed formulations How were mortalities disposed? Farm’s turkey shipments suspended since Aug 13 First Hypothesis: on farm feed mix up

5. USDA: Food Safety & Inspection Service (FSIS) + FDA: DET-DO and CVM + MDARD: Feed and Animal Industry ___________________________________________ = Lots of questions, few answers Solution: Regular Multi-Agency Conference Calls 1 st call: August 21

6. MDARD & FDA DET-DO @ Index Farm Root cause? Lasalocid inventory reconciliation ~ 450 tons turkey feed removed MDARD collects official and retain samples Finished feeds – turkey and swine Ingredients USDA FSIS @ Processor When can farm begin shipping turkeys again? Clears farm on August 28

7. MDARD Lab Low levels lasalocid in finished feeds Dry ingredients clean Unable to run fats and oils for lasalocid – no official methods Michigan University, Diagnostic Center for Population and Animal Health (MSU DCPAH) Can qualify the presence of lasalocid in grease MDARD sends grease samples to MSU DCPAH

9. 1,510 g/ton lasalocid detected in swine feed Lasalocid is NOT approved for swine Lasalocid detected in grease samples MDARD contacts Index Farm 5,000 pigs shipped weekly Farm agrees to not ship pigs to market until more known about withdrawal period for swine

10. FDA validation of quantifiable method - 6-8 weeks MDARD, FDA and USDA continue investigations What is the start date? 3 grease suppliers Index Farm Removes all grease from swine formulations Submits swine liver samples to 2 laboratories Submits Reportable Food Registry

11. Food Animal Residue Avoidance Databank (FARAD) contacted Recommend 28 day withdrawal time FDA CVM makes withdrawal recommendation to USDA 28 day withdrawal time “out of an abundance of caution” Index Farm 20,000 pigs impacted September 16 start date

12. Samples collected from all 3 grease suppliers Only 1 supplied grease in early August to farm Samples show presence of lasalocid MDARD issues stop sale order Firm shipped grease to 11 locations MI, IL, IN and OH FDA DET-DO and MDARD discuss recall options with firm

13. Michigan Firm: September 26 recall MDARD stands up an Incident Management Team for the incident. FDA continues traceback investigation at out of state sources Multi-Agency Conference Calls held 3x per week Indiana, Illinois and Ohio join calls Shur-Green Farms in Ohio issues recall on October 23

14. Lascadoil – an industrial processing waste oil From the Press Release: loads of Soyoil containing Lascadoil that was intended for commercial use (biofuels) may have crossed over to the feed ingredient stream

16. Investigation is still ongoing Index Farm lost a total of 50,000 turkeys due to the contamination Future recalls anticipated November 12 – MDARD held a compliance conference with Michigan grease supplier.