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Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Developing The Artificial Cytoskeleton: adaptation through morphogenesis in diatoms.

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Presentation on theme: "Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Developing The Artificial Cytoskeleton: adaptation through morphogenesis in diatoms."— Presentation transcript:

1 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Developing The Artificial Cytoskeleton: adaptation through morphogenesis in diatoms Katie Bentley, Chris Clack: CS, UCL Eileen J. Cox: Botany, NHM

2 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Background Hand design of robots and artificial agents - Bad idea ! Interest in how well adapted forms in nature have occurred: Evolution: evolutionary robotics, co- evolution… No geno-pheno mapping Development: L-system, GRN… Multicellular, no life-time adaptation

3 Background Look a level lower… How are unicells able to dynamically adapt? How can they produce complex morphologies? Can we harness this ability to produce Alife agents with adaptable morphologies? Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 - Mechanism: cytoskeleton - YES !

4 Cytoskeleton STRUCTURAL:ACCESSORY: Microfilaments (Actin)- Actin Binding Proteins (ABPs) Microtubules (Tubulin)- Microtubule Binding Proteins (MAPs) Intermediate filaments- Motor proteins ATP ADP : fuelRegulated by [CA 2+ ] Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004

5 Cytoskeleton Dynamic interaction of these elements is the mechanism for… Cell motility Cell division Cell Polarization… Dynamic nature gives cells adaptive powers a vertebrate skeleton cannot allow Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Structural system (dynamic) Transport system (dynamic)

6 Artificial Cytoskeleton Developed alongside biological experiments (Eileen) Dynamical, spatial computational system (C/C++, OpenGL, GLUT, GLUI): - swarm rather than CA Structural proteins interact with concs of accessory proteins and ions in 3D voxel space. Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004

7 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004

8 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Experiments Diatom specific model additions… AC interacts with plasmalemma, mitochondria and other organic material: - affects silica deposition… - Adaptation to osmotic stress - Adaptation to nutrient depletion…

9 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 Experiments Based on theory and model in: Bentley, K. et al (2003). Nature's Batik: A Computer Evolution Model of Diatom Valve Morphogenesis. Journal of Nanoscience and Nanotechnology. In Press.

10 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004 

11 Bentley, K. CS, UCL The Artificial Cytoskeleton: NIC – 10/11 Feb 2004


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