1. sickle cell anemia

5. Causes  Hemoglobin S  Recessive  11 th chromosome  Single letter change  Valine—glutamic acid http://www.youtube.com/watch?v=9UpwV1tdxcs http://www.youtube.com/watch?v=2o3wQ- mJZuQ&feature=related

6. Symptoms  Sickle blood cells cause:  Blocking of blood flow  Pain--Crises  Infection  Organ damage  Swelling

7. Treatment  None widely available  Stem Cell Transplants—few cases

8. Prognosis  Before—death between ages of 20 and 40  Now—live until 50-60

9. Who’s got it?  Most likely: African, Mediterranean, South and Central American, Caribbean, Middle Eastern people

10. Do you want to know?  Dangerous disease  Early death  Extreme pain

11. Genetic Testing  Pain  Treatment-$$$  Death  No liability  Low emotional impact  Medications

12. Carrier vs. Patient  Carrier=okay (don’t strain)  Patient=bad (crises, pain)  Codominance-ish

13. Pooja Joshi and Matthew Dozer Period 3 Mr. Hames November 2011