1. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 1 Designing of anti-counterfeiting & Compliance solutions in a comprehensive patient centric healthcare system Prabuddha Ganguli, Ph.D. CEO – Vision IPR & Director - Bilcare Singapore And Praful Naik, Ph.D. CSO - Bilcare Limited

2. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 2 Backdrop Global Pharma industry is undergoing a major transformation in all quarters of its value chain –Legitimate competition involving emerging technologies –Innovation processes are getting expensive – –IPR & public policy taking centre stage –Clandestine industry of counterfeiting is a major barrier to genuine access to innovations & healthcare

3. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 3 Impact of Counterfeit Growing menace in developing & least developed countries – Revenue Loss – from 10% to 30% Contribution Loss – almost equals to industry profit Brand credibility ??? Developed World also significantly impacted

4. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 4 Perils of Counterfeit on Healthcare look-alikes with “variable to no efficacy” are detrimental / fatal Re-labeling/packaging of rejects/expired drugs: fairly common practice Innovations in anti-counterfeiting: non-transparent for the consumer Current Covert & Overt Technologies are open ended & generic –eg.: Ineffectiveness of Holograms Track & Trace: Implementation challenges & not fool-proof in isolation –eg.: RFID

5. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 5 Challenges Counterfeit is increasingly recognized as a key challenge as it leads to –Non-Compliance resulting in frequent change of prescription; drug resistance – secondary care leading to significant increase in healthcare management cost Medicine as total cure recognized as Myth –Imbalance in diet and fitness management are major contributing factors Solutions must –Empower consumer to participate in the global action on anti-counterfeiting –Be Commercially sustainable & yet simple for operability by the consumer –Be capable of addressing multiple concerns

6. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 6 Challenges… Avoidable Complications & Hospitalization Enhanced burden of healthcare costs on Nations Anti-Counterfeit – Who should tackle? – Producer, Regulator, Patient, Pharmacist or the Doctor? –Government, Healthcare Organizations, Insurance Cos.? “Means & process to facilitate Collaborative efforts of all stake holders”

7. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 7 Clinical Research & Development of new medicines / therapies –Impact of Non - Compliance –Real time patient feedback –Timely professional interventions “Means & process to facilitate Robust Clinical Research Management” Challenges…

8. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 8 Patient Doctor Care Giver Pharmacy Hospital Insurer Stake Holders Manufacturer The Current Healthcare Scenario

9. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 9 Bilcare’s Approach Patents Pending

10. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 10 Patient Doctor

11. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 11 Patient Doctor Interactive Companion Device

12. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 12 Patient Doctor Healthcare Knowledge Management System Interactive Companion Device

13. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 13 Patient Doctor Compliance Support Interactive Companion Device Healthcare Knowledge Management System

14. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 14 Patient Doctor Compliance Support Anti - counterfeit Support Interactive Companion Device Healthcare Knowledge Management System

15. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 15 Patient Doctor Compliance Support Anti - counterfeit Support Interactive Companion Device Healthcare Knowledge Management System

16. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 16 Pharmacy Compliance Support Care giver Anti - counterfeit Support Patient Doctor Insurer Manufacturer Hospital National Health System Distribution Integrated Interactive Companion Device Healthcare Knowledge Management System

17. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 17 Key Deliverables Registration & Exclusivity of the Companion device Authentication of medicine User compliance inclusive of Diet & Fitness Online patient feedback E- prescription Generation and transmission of customized reports Secured data & Information for stake holders Real-time data in raw and analyzed form

18. A Bilcare Singapore Initiative Bilcare © 2007 Privileged Information The Oxford Conference on Innovation & Technology Transfer for Global Health, Oxford, U.K. September 9 – 13, 2007 18 Key to Success For effective & successful implementation Participation of major stakeholders Involvement of regulatory & governing agencies –WHO, NHS & their likes Test implementation in a region Planned transfer of technology Blending of various local regional requirements Awareness & Training support